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Texas indigenous Jim Allison was awarded the 2018 Nobel Prize in Physiology or medication this week for constructing an "wholly original precept for cancer remedy" that unleashes a affected person's immune system to bombard tumors.

Allison, a professor on the school of Texas M.D. Anderson melanoma seat in Houston and a median blues harmonica player, developed the groundbreaking cancer treatment referred to as "immune checkpoint therapy" along with fellow Nobelist Tasuku Honjo of Kyoto college.

The Nobel has been awarded for melanoma research in the past, but here is the first time an precise remedy for melanoma has been rewarded. "by using stimulating the skill of their immune outfit to bombard tumor cells, this year's Nobel Prize laureates hold centered a completely original principle for melanoma therapy," pointed out the Nobel committee.

Allison's leap forward become the structure of an antibody to obstruct the "checkpoint" protein on T cells, releasing those cells to assault melanoma. This led at once to the primary immune checkpoint inhibitor drug, Ipilimumab, accepted with the aid of the food and Drug Administration in 2011 for the remedy of late-stage melanoma. This and other immunotherapy medication hold given that been used to deal with sufferers suffering from lymphoma, lung, renal and other styles of cancer.

We reached out to the 70-12 months-historical Nobel laureate this week to congratulate him, but additionally to debate how primary science—and the federal and condition funding behind so tons of it—become essential to his very nearly 40 years of analysis, and scientific and scientific growth in universal.

"simple science gives the basic foundation for principal advances in clinical medicine," Allison noted. "My early analysis in T-telephone biology was funded via the national melanoma Institute. simple analysis is rarely regularly understood. it's knotty and requires a thick epidermis to undergo failure after failure in quest of success. attending to solutions requires cash and persistence, but the payoff has the possibility to shop many, many lives."

The country wide Institutes of fitness, Allison mentioned, "is still the biggest funding mechanism of medical analysis on this planet." but he too praised his domestic state, announcing, "Texas diagnosed the possibility to accelerate discovery and fundamental science with the aid of investing $3 billion over 10 years through the cancer Prevention and analysis Institute of Texas."

Biotech and pharmaceutical companies, explained Allison, fund the late-stage analysis that brings well-developed treatments to clinical trial—and philanthropy is too by far constructive. "but without that early funding of basic science from the executive, lots of the treatment options that presently deal with hundreds of thousands of cancer patients international simply wouldn't exist," he observed.

We reliance Allison that investing in simple science is among the top-rated uses of federal and condition taxpayer cash. When politicians discourse of slicing funding to the country wide Institutes of health and different funders of basic research, they aren't "draining the swamp" however strangling the goose that lays the golden egg.

The Dallas Morning information


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The tuition of Vermont these days introduced an creative partnership to set up the college’s first seat of Excellence, to exist able to expand statistics science analysis on human well being.

MassMutual being insurance enterprise is featuring $5 million to establish the MassMutual middle of Excellence for advanced programs and statistics Science to analysis human well being through records evaluation. the brand original initiative will expand the school’s Vermont complicated methods middle, which became created in 2009.  MassMutual Chief data Scientist Sears Merritt says the brand original middle is intended to exist the gold regular to retort human health questions.  “They occupy a very pass-disciplinary or perhaps interdisciplinary strategy to doing the science that’s associated with these things. So now not most effectual does that seat focal point on working with mathematicians and physicists and desktop scientists, but they’re additionally focused on working with economists, folks in fields of medication and different areas of sociable sciences. From their factor of view it’s in reality only if you occur to accept these diverse agencies together and seat of attention on answering the questions during the lens of records science and knotty methods are they definitely equipped you know to accept a hold of answers.”

UVM advanced techniques Director Peter Dodds says the original partnership makes a speciality of individuals-founded research that will assist trade collate expansive amounts of data to create holistic guidelines and advantages.  “So there’s some stuff the plot we’ll exist in a position to command they assume there’s a kindly simple science perhaps about longevity or about how individuals movement around the U.S. after which for MassMutual you understand there are some extra inevitable things about a course to cost people according to counsel. So as an sample they exhaust blood exams usurp and so could a proxy exist created? can you substitute a a tiny onerous invasive manner of finding out suggestions about people? as a result of in the finish you recognize they’re assessing risk. So there are elements there that might back them. Then there’s additionally working towards of scholars.  It’s a capstone for their academic choices structure utterly original courses about records science or about complicated techniques.”

Merritt provides that the UVM core will occupy a more contemporary strategy with computational outfit that may investigate themes just dote the hyperlink between actual and pecuniary health; detect warp and measure equity and measure mortality possibility.  “If we’re a success with answering some of those questions #1 society as a whole I believe stands to benefit. Their speculation is those merits then trickle down into their industry and provides consumers greater entry to items and capabilities which are greater tailor-made to their wants.  It gives you know society as an entire stronger counsel to consider about how to craft guidelines and mechanisms that permit us to tackle behavioral points of what’s occurring in their society, once again, to more desirable complete and sundry’s lives and relieve folks are animated more desirable.”

The $5 million may exist offered over 5 years starting in 2019.  it's the greatest present given to the university of Vermont up to now with the aid of a corporate supporter. 


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Nobel Prize laureate James Allison did the bulk of his award-profitable immunotherapy analysis out of a modest lab at UC Berkeley within the Nineties, working with a group of scrappy submit-docs who hold been bucking regularly occurring lore across the office of the immune system in fighting melanoma.

Their work, his group individuals now recollect, became propelled with the aid of the excitement of discovery and a virtually artless enthusiasm. greater than 20 years later, they now hold the area’s most prestigious stamp of approval.

The Nobel in physiology or medication turned into granted to Allison, together with jap immunologist Tasuku Honjo, Monday morning. both scientists developed separate techniques for turning on the immune device to bombard tumors that were unresponsive to different melanoma-killing remedies. Allison worked at UC Berkeley from 1985 until 2004, and is now on the school of Texas MD Anderson melanoma center.

“here is very powerful replete set for the labor that they did returned then,” spoke of Matthew Krummel, a u.s. pathologist who, as a graduate and post-doctoral scholar, labored intently with Allison at UC Berkeley in the ’90s. “We knew it changed into a huge deal, they knew they hold been truly making progress in areas the plot no one would hold anticipated. They knew this turned into not a pedestrian discovering, but whatever thing basically earthchanging.

“It’s high-quality to hold this acknowledgment,” he mentioned.

Allison’s analysis ended in the primary commercially accessible immunotherapy on earth, a drug referred to as Yervoy that is primarily used to combat epidermis melanoma that has spread to different constituents of the physique. The drug, accredited with the aid of the FDA in 2011, fees greater than $one hundred,000 for a round of remedy and doesn't labor for complete patients, however then again was hailed as a wonderful addition to the arsenal of outfit — including chemotherapy, surgery and radiation therapy — used to fight cancer.

Immune cells hold molecular receptors — practically on-off switches — that cease them from taking action. These receptors, which scientists hold near to title immune checkpoints, are key to holding a robust immune response: it will exist challenging for immune cells to exist overactive and bombard an individual’s own body.

however the checkpoints can avoid the immune cells from doing their jobs and going after tumors. The labor by Allison and Honjo is in developing checkpoint inhibitors — molecules that well-nigh circle key immune cells again on, for a length of time, to battle an aggressive melanoma.

Checkpoint inhibitors now are used to deal with distinctive cancers, apart from melanoma.

“There was really a ton of skepticism in the 1990s that you simply might ever finish this with the immune system,” said David Raulet, director of UC Berkeley’s Immunotherapeutics and Vaccine research Initiative. “So this turned into really a sea change. It spurred a change of the cancer therapy box. We’re very pleased with (Allison’s) accomplishments as a result of they created an entire original category of cancer therapy.”

Scientists who worked with Allison at UC Berkeley recalled an energized, highly encouraged lab ambiance, the plot youthful researchers had been encouraged to let curiosity compel their work.

all over the world, most of the exact scientists in immunology had determined that the immune outfit was too knotty to exist readily harnessed as a device to combat cancer. Allison’s crew wasn’t always attempting to buck that line of pondering — they had been just eagerly exploring the primary mechanics of immunity, talked about Russell Vance, director of the cancer research Laboratory at UC Berkeley who labored briefly in Allison’s lab as a graduate student in molecular and telephone biology.

“It became a thrilling time in the lab,” Vance mentioned. “It felt dote they had been revealing the simple mechanisms about how the immune system works. dote they hold been finally understanding its basic nuts and bolts. these kinds of discoveries, once they’re found, they’re institute out invariably. It feels momentous.”

Vance observed he woke up at 2:30 Monday morning to watch the Nobel announcements on-line — sitting in the reticent in his apartment, whereas his family unit slept. He let out a yelp of joy when the names hold been revealed.

Krummel talked about Allison had a “laissez-faire” angle towards the scientists in his lab. He would mostly travel away his individuals on my own to ensue their personal route, then dive in to relieve power their labor forward when he saw exciting results.

“He’s an pattern scientific opportunist, and that i connote that in complete the usurp ways. He’s cognizant of that price of what you’re doing,” Krummel stated.

The labor turned into performed out of UC Berkeley’s being Science Addition facility, built in 1988, just a few years after Allison got here to the campus. His crew worked broadly speaking in a fourth-floor lab, however they spent lots of time on the seventh floor, too, where the laboratory mice were housed and the scientists had “the top-rated view on campus,” Krummel said.

UC Berkeley at the time wasn’t regarded the class of establishment that produced scientific marvels — leaps in fundamental science, sure, however with out a clinical college or sanatorium on web site, the scientists couldn’t Put their discoveries into play in human subjects. basically, that was what ultimately compelled Allison to travel away. When his labor in immunotherapy had improved beyond the lab, he moved to Memorial Sloan Kettering in long island to aid oversee human medical trials.

In a press conference Monday morning, Allison spoke of it became pleasing to descry any such profound payoff for his lengthy years of labor — now not simply within the Nobel, but in the countless patients whose lives hold been extended by means of his discovery.

In actuality, though, curing cancer become in no course what inspired his work, he added.

“What definitely motivates us as scientists is the exigency to know some thing that no one else knows,” Allison said. “optimistically, it’s some thing essential.”

Erin Allday is a San Francisco Chronicle staff author. electronic mail: eallday@sfchronicle.com


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One-to-One Laptop Initiatives Boost Student Scores, Researchers Find | killexams.com true questions and Pass4sure dumps

Chromebooks-Montgomery-County-classroom-blog.jpgBy Leo Doran and Benjamin Herold

Efforts by K-12 schools to give every student a laptop computer increased student achievement and gave a modest boost to their "21st century skills," according to a first-of-its-kind meta-analysis of 15 years' worth of research studies.

"It's not dote just providing a laptop to every student will automatically extend student achievement, but they find that it's the first step," said Binbin Zheng, an second professor of counseling, educational psychology, and special education at Michigan condition University.

Using statistical techniques to analyze already-completed studies, Zheng and her colleagues institute that 1-to-1 laptop programs on average had a statistically significant positive impact on student test scores in English/language arts, writing, math and science. The limited number of rigorous quantitative studies available to analyze connote that those findings are not definitive, but they are clearly a kindly mark for 1-to-1 proponents and underscore the exigency for more study, Zheng said.

A further review of 86 additional papers by the researchers, meanwhile, institute some modest evidence of other positive benefits associated with giving laptops to students, including increased student technology use; more student-centered and project-based instruction; greater student engagement; and better relationships between students and teachers.

The analysis focused solely on 1-to-1 laptop efforts. The researchers cautioned that their results are not generalizable to other devices such as tablets, desktop computers, and smartphones.  

The original findings rush counter to the skepticism about educational technology expressed by many researchers and practitioners. A raft of prior studies, for example, hold shown that even when technology is present in classrooms, teachers are gradual to transform their practice, instead using technology primarily to construct administrative tasks and existing forms of instruction more efficient.

The original analysis has the potential to reshape the debate about ed-tech's impact, said Elliot Soloway, a computer science professor at Michigan University who has spent decades studying classroom technology.

"This is one of those definitive studies that comes along every 20 years," Soloway said. "Schools are going to exhaust [the findings] to warrant the run to 1-to-1."

Rapid Growth of 1-to-1 Student Computing

One-to-one student computing was first introduced to K-12 schools in the United States in the late 1990's. In 2002, Maine became the first condition to launch a statewide program.

The trend has since gathered steam: In 2013 and 2014 alone, schools purchased more than 23 million laptops, tablets, and Chromebooks for exhaust by students and teachers in the classroom (and sometimes at home.)

Generally, the goal is to enable teachers and software to deliver more personalized content to students, to boost students' technology skills, and to empower children to finish more knotty and creative work.

A handful of high-profile 1-to-1 disasters resulting from indigent purchasing plans, rank planning, and a want of transparent academic vision hold raised questions for schools about the wisdom of the approach, however.

And some research has been less than encouraging. A 2009 survey by the National seat for Education Statistics, for example, institute that classroom technology was used for drill of basic skills far more often than for design and creation. A recent study by the Organization for Economic Cooperation and progress institute that countries where 15-year aged students exhaust computers most in the classroom scored the worst on international math and reading tests.

In an attempt to definitively determine the impact of K-12 1-to-1 initiatives, Zheng and her colleagues reviewed 96 journal articles and doctoral dissertations published between January 2001 and May 2015.

Just 10 of those studies met the researchers' criteria for inclusion in the statistical meta-analysis of 1-to-1 laptop initiatives' impact on student achievement, reflecting the still-very-limited research basis on student computing initiatives.

"A disproportionate amount of the research to date on this topic consists of miniature case studies in one or a handful of schools," Zheng and her colleagues wrote in their study, titled "Learning in One-to-One Laptop Environments: A Meta-Analysis and Research Synthesis," published online earlier this year in the academic journal Review of Educational Research. 

Still, there were enough historical findings to conclude that 1-to-1 laptop programs helped improve students' academic achievement by an overall outcome size of .16 gauge deviations—a design that Zheng said indicates statistical significance, but is noticeably less than the outcome sizes of other established interventions, such as miniature class sizes or individual tutoring.   

The researchers institute the following outcome sizes for specific subjects:

  • English/language arts, by .15 gauge deviations
  • Writing, by .20 gauge deviations
  • Math, by .17 gauge deviations
  • Science, by .25 gauge deviations.
  • Reading, by .12 gauge deviations
  • The impact on students' reading achievement was positive, but not statistically significant. Only two studies included science results that could exist analyzed.

    The results are "small but noteworthy," Zheng said.

    Measuring impact Beyond Test Scores

    The researchers too looked beyond test scores, reviewing 85 additional studies that did embrace an empirical examination of 1-to-1 laptop initiatives' impact in K-12 schools, but did not embrace an experimental design and/or quantitative results.

    Among the findings from that review: 

  • A 1-to-1 laptop environment often led to increased frequency and breadth of student technology use, typically for writing, Internet research, note-taking, completing assignments, and reading.
  • Students used laptops extensively throughout the writing process, expanding the genres and formats of their labor to embrace writing for email, chats, blogs, wikis, and the like.
  • Student-centered, individualized, and project-based learning appeared to extend in at least some instances of 1-to-1 laptop rollouts.
  • Student-teacher communications (via email and Google docs, for example) and parental involvement in their children's school labor increased in some instances.
  • Students expressed "very positive" attitudes about using laptops in the classroom, as findings consistently showed higher student engagement, motivation, and persistence when laptops were deployed to complete students.
  • Students' technology and problem-solving skills improved and their ownership of their own learning increased, according to some evidence.
  • There were mixed findings on whether 1-to-1 laptop programs helped overcome inequities among students and schools.
  • Those results should exist interpreted with caution, the researchers said, because they tended to reckon on observation, survey, and interview data.

    "There was a wide consensus in the studies they reviewed that exhaust of laptops promotes 21st-century learning skills," the authors wrote. "However, studies rarely attempted to operationalize and systematically measure the growth of 21st-century skills in laptop students compared with control students."

    Leslie Wilson, the CEO of the One-to-One Institute, a nonprofit that consults with schools and districts, said she was "thrilled" to descry the original research, though she cautioned that educational leaders shouldn't leap to conclude that going 1-to-1 is enough on its own to extend student achievement.

    For such a program to exist effective, she said, schools must focus on crafting comprehensive plans that cover everything from infrastructure to curriculum to pedagogy to professional development.

    And the true benefits of giving every student an access to a computer, contended Soloway of the University of Michigan, near when school run from "instructive" to "constructive" learning, or from "teaching kids to recall something to teaching them how to design something out."

    To best measure the extent to which that change is taking place, Zheng said, researchers and educators will hold to search beyond standardized test scores.

    Hopefully, she said, the original research will prompt further application to develop assessments for students' digital literacy skills, as well as their creativity, independence, and leadership.

    "Many of the benefits of 1-to-1 laptop programs are not detected by standardized tests," Zheng said. "For the many programs whose purpose is to relieve students exist a better 21st-century citizen, they exigency to develop and exhaust corresponding measurements."

    Students at Ridgeview Middle School in Gaithersburg, Md. exhaust laptops in class in 2014. --T.J. Kirkpatrick for Education Week

    See also:

    Follow @BenjaminBHerold for the latest advice on ed-tech policies, practices, and trends. 


    Community calendar, Oct. 5 | killexams.com true questions and Pass4sure dumps

    * preserve up with complete the goings-on around town at davisenterprise.com/events.

    * Friday, Oct. 5: The Avid Reader in Davis is hosting an author event with Stephen Jordan and his debut novel set in San Francisco in the 1980s, “Tatiana and the Russian Wolves.” The hour-long event begins at 7:30 p.m. at The Avid Reader, 617 Second St. in downtown Davis. It is free and open to the public. Refreshments will exist provided. For more information, call 530-758-4040 or visit avidreaderbooks.com.

    * Saturday, Oct. 6: A obstruct Party, with creation, design, and play with Lego blocks, begins at 2 p.m. at the Stephens branch Library, 315 E. 14th St. in Davis.This is a drop-in program. Parents and caregivers are encouraged to remain and play alongside their children. It is not recommended for children under 3.

    * Saturday, Oct. 6: The next Davis Night Market will occupy plot at the Sudwerk Brewing Co.’s The Dock Store, from 5 to 10 p.m. The event is a co-production of Sudwerk and The kindly Scoop, in partnership with the City of Davis. The market features local artisans and businesses for an evening of music, food, beer, community and handmade goods. The market will exist Oktoberfest themed, with German food and a specially brewed beer for the event. It will raise funds to back The Pantry at UC Davis, with 10 percent of event sales proceeds being donated.

    * Saturday, Oct. 6: The Avid Reader will be introducing David Wystan Owen and his original novel “Other People’s freight for Affairs: Stories” at 7:30 p.m.  at The Avid Reader, 617 Second St. in downtown Davis. It is free and open to the public. For more information, call 530-758-4040 or visit avidreaderbooks.com.

    * Sunday, Oct. 7: In recognition of national Pregnancy and Infant Loss Awareness Month, the Yolo County Health & Human Services Agency Fetal/Infant Mortality Program invites the community to a remembrance ceremony and butterfly release from 1 to 4 p.m. at the Davis Cemetery and Arboretum, 820 Pole Line Road in Davis. For more information call 530-666-8522.

    * Monday, Oct. 8: Preet Bharara, who served as a U.S. Attorney for the Southern District of original York from 2009 to 2017, and earned a national reputation for taking on public corruption and Wall Street crime, will discourse at the Mondavi seat at 7 p.m. Tickets are $25 to $45 general, available at www.MondaviArts.org or by calling 530-754-2787.

    * Monday, Oct. 8: The Open Door educational program, Pink Speaker Series, welcomes Melissa Williams, an oncologist with the Sutter Medical Foundation in Davis and Sacramento, who will discourse on “What Are The Latest Treatments and Research Developments for Breast Cancer?” The program will exist at 7 p.m. at University Covenant Church, 315 Mace Blvd., at Alhambra Boulevard in Davis. call 530-304-2746 for more information.

    * Monday, Oct. 8: The Prostate Cancer back Group meets at 7 p.m. at the Stephens branch Library, 315 E. 14th St. in Davis.This group helps back prostate cancer patients and their caregivers. Dr. Winifred Wong, of Travis Air compel basis will debate treatment options, recovery and side effects. Wong is director of the joint radiation oncology clinic and is co-investigator in nine cancer research studies, including evaluation of prostate cancer treatment effectiveness. For information, visit yoloprostate.net, or call Ray Biancalana at 530-756-6408 or Gil Walker at 530-661-6449.

    * Tuesday, Oct. 9: The Davis Peripheral Neuropathy back group will screen the documentary “Forks Over Knives” from 3:30 to 5 p.m. at the Davis Senior Center, 646 A St. in Davis. complete are welcome. For further information, contact Mary Sprifke at 530-756-5102.

    * Tuesday, Oct. 9: A seasonal retreat, Autumn Gratitude, features SoulCollage, an intuitive collage process, along with reflection, sharing and seasonal refreshments, from 6 to 8:45 p.m. in the Fireside margin at Davis Community Church, Fourth and C streets. The cost is $40, including materials and seasonal refreshments.

    * Tuesday, Oct. 9: Free your body, wit and heart: exhaust your breath with gentle Viniyoga movement and meditations from the Sutra on replete Awareness of Breathing to lower stress and build kindful resilience at Davis Shambhala Meditation Center, 133 D St., from 6 to 7 p.m. every Tuesday. Drop in or call 415-315-9871 for information.

    * Tuesday, Oct. 9: The Photography Club of Davis will meet at 7 p.m. at the Davis Senior Center. The public is invited to attend; it is a free event. Their presenter for the evening will exist Laurie Friedman. Freiedman will expose her images from a trip to Antarctica; Santiago, Chile; and Buenos Aires, Argentina, so there will exist photos from those colorful countries as well. She is a past director of the Travel Division of the Sierra Camera Club in Sacramento, past president of the Photography Club of Davis, and current convener of the University Farm set relish for Travel section.

    * Wednesday, Oct. 10: Project Linus meets to construct blankets for children who are seriously ill, traumatized or otherwise in exigency from 1:30 to 3:30 p.m. at the Davis Senior Center, 646 A St. For generic information, drop-off location questions, or fabric and yarn donations, contact Diane McGee at [email protected] or 530-753-3436.

    * Wednesday, Oct. 10: The Korean Language and Culture Class, meets at 4 p.m. in the Stephens branch Library, 315 E. 14th St. in Davis. This group is for adults who wish to gain a basic lore of Korean language and culture.

    * Wednesday, Oct. 10: Travis Credit Union’s free pecuniary literacy string features “Psychology of Spending” at 6 p.m. in the Blanchard margin at the Stephens branch Library, 315 E. 14th St. in Davis. Psychologists hold institute that there are several forces that govern their consumer conduct and antecedent us to construct decisions that are not necessarily rational or in their best interest. However, understanding why they buy what they buy can relieve us construct better decisions in the future.

    * Wednesday, Oct. 10: Sutter freight at Home Hospice offers a Grief and the Holidays workshops in Davis from 6:30 to 8 p.m. Adults who hold lost a loved one and are anticipating having a difficult time at the holidays are invited to this workshop. The workshops are available to complete community members regardless of whether their loved one received hospice care. There is no freight to join. For information and to pre-enroll, call Bereavement Services at 916-388-6215 or 916-388-6243.

    * Thursday, Oct. 11: vigorous Older Adult Wisdom Circle meets att 10:15 a.m. at the Stephens branch Library, 315 E. 14th St. in Davis. This group meets monthly to debate and explore the conscious aging movement.

    * Thursday, Oct. 11: The library’s Teen Advisory Group for ages 13-18 meets at 4 p.m. Teens meet every second Thursday to debate and develop ideas for teen programs, special projects, recommendations for the collection, and more at the Stephens branch Library, 315 E. 14th St. in Davis.

    * Thursday, Oct. 11: The Sierra Club Yolano Group invites everyone to a potluck dinner and community forum on diversity and inclusion at 7 p.m. Thursday, Oct. 11, in the Blanchard margin in the Stephens branch Library, 314 E. 14th St. in Davis (near Davis lofty and Veteran’s Memorial Center). Bring your favorite dish to share and, to relieve us strive to construct this a “zero waste” event, gladden bring your own plates, cups, utensils and a cloth napkin. The Yolano Group will provide beverages and reusable tableware for those in need.

    * Friday, Oct. 12: Anime After Hours for ages 13-18 begins at 5:30 p.m. in the Blanchard margin at the Stephens branch Library, 315 E. 14th St. in Davis. The group will watch three episodes of the anime of your choice. There is free pizza and popcorn while supplies last.

    * Friday, Oct. 12: The Avid Reader will host UC Berkeley professor Richard A. Walker, author of “Pictures of a Gone City” for a book event. The hour-long event begins at 7:30 p.m. at The Avid Reader, 617 Second St. in downtown Davis. It is free and open to the public.For more information, call 530-758-4040 or visit avidreaderbooks.com for more information.

    * Friday, Oct. 12: Yolo Cabrillo Civic Club No. 26 will host a bunco fundraiser at Holy Rosary Parish Hall, 315 Walnut St. Doors open at 6 p.m., games start after refreshments are served. Club members are asked to donate a prize. The preregistration $20 entry fee includes delightful soup, sandwiches, chips, soft drinks, water and bunco. Game prizes and a fun raffle will allotment of the night. Cost will exist $25 at door if not preregistered. complete proceeds will benefit patient services for Yolo County Hospice. To preregister, contact Shaari, 383-3874.

    * Saturday, Oct. 13: relish 2018 will feature samples of the region’s finest foods and beverages from wineries, craft breweries, meaderies, cider makers, restaurants and other food vendors from 5 to 7 p.m. The event is hosted by the Robert Mondavi Institute at UC Davis in the kindly Life Garden. Guests will exist welcomed with a commemorative tasting glass to exist pleased sips of their favorite beverages along with a variety of sample bites and live music by Jazz Gitan, a Django Reinhardt-inspired gypsy jazz quartet. Tickets are $35 general, $25 for students with ID, 21 and over.

    * Saturday, Oct. 13: Listen to stories near alive with sound effects, dramatic narration and masked movement at “Voice of the Wood: Halloween” nascence at 4 p.m. at the Stephens branch Library, 315 E. 14th St. in Davis.

    * Saturday, Oct. 13: The Avid Reader presents an upcoming event with Francis Pring-Mill and his original book “In Harmony with the Tao: A Guided Journey into the Tao Te Ching.” The hour-long event begins at 7:30 p.m. at The Avid Reader, 617 Second St. in downtown Davis. It is free and open to the public. call 530-758-4040 or visit avidreaderbooks.com for more information.

    * Saturday, Oct. 13 — Sunday, Oct. 14: Just as CPR helps you assist an individual having a heart attack, Mental Health First Aid helps you assist someone experiencing a mental health or substance use-related crisis. Learn risk factors and warning signs for mental health and addiction concerns, strategies for how to relieve someone in head and non-crisis situations, and where to circle for help. There is no cost, but it organizers request registration for this two-day class at davis.shambhala.org so they hold an plan of attendance. Meet from 8:30 a.m. to 1 p.m. Saturday, and 12:30 to 5 p.m. Sunday at Davis Shambhala Meditation Center, 133 D St., Suite H (above First Northern Bank).

    * Tuesday, Oct. 16: Free your body, wit and heart: exhaust your breath with gentle Viniyoga movement and meditations from the Sutra on replete Awareness of Breathing to lower stress and build kindful resilience at Davis Shambhala Meditation Center, 133 D St., from 6 to 7 p.m. on every Tuesday. Drop in or call 415-315-9871 for info.

    * Tuesday, Oct. 16: The Davis Genealogy Club invites the public to a free presentation by celebrated returning speaker, genealogist James Baker, on “The Best Online Sites for German Genealogy” at 1 p.m. at the Davis Senior Center, 646 A St. Visit DavisGenealogy.org for more or call Lisa Henderson at 530-753-8943.

    * Wednesday, Oct. 17: The Korean Language and Culture Class, meets at 4 p.m. in the Stephens branch Library, 315 E. 14th St. in Davis. This group is for adults who wish to gain a basic lore of Korean language and culture.

    * Saturday, Oct. 20: The Davis Phoenix Coalition will host a free Upstander Carnival for pre-K through elementary-aged children from 10 a.m. to 1 p.m. Saturday, Oct. 20, at the Davis Central Park 401 C St. intimate carnival games will feature an added element of learning to exist an “upstander” — someone who stands up to bullying.  There too will exist free prizes, tote-bag giveaways to early arrivers and a bounce house. Sponsors are sought who share in the mission of promoting safe and inclusive spaces for complete to relieve as volunteers and to share information about their organization. For more information, email [email protected]

    * Saturday, Oct. 20: A fermented foods workshop, “Building Community Ferment,” begins at 11 a.m. at the Stephens branch Library, 315 E. 14th St. in Davis.

    * Saturday, Oct. 20:  Davis Origami Group meets at 1 p.m.at the Stephens branch Library, 315 E. 14th St. in Davis. complete can learn to fold paper into different shapes. The first hour is for beginners and it is open to complete ages and abilities.

    * Saturday, Oct. 20: Caturday at the Library begins at 2 p.m. at the Stephens branch Library, 315 E. 14th St. in Davis. This is an afternoon of joyful celebration of the pets in their lives, including kitten and cat adoptions, a showing of the documentary “Kedi,” a cat-themed family fable time, kitty cat crafts for kids and adults (including origami with the Davis Origami Group), and cat and dog mini-lectures by UC Davis School of Veterinary Medicine’s Melissa Bain, Emma Grigg, and Mikel Delgado.

    * Sunday, Oct. 21: Yolo County Master Gardeners meet at 2 p.m. at the Stephens branch Library, 315 E. 14th St. in Davis. complete are invited to bring gardening questions and learn better gardening techniques.

    * Tuesday, Oct. 23: Free your body, wit and heart: exhaust your breath with gentle Viniyoga movement and meditations from the Sutra on replete Awareness of Breathing to lower stress and build kindful resilience at Davis Shambhala Meditation Center, 133 D St., from 6 to 7 p.m. on every Tuesday. Drop in or call 415-315-9871 for info.

    * Wednesday, Oct. 24: The Hanna and Herbert Bauer Memorial Garden will host a free worm composting class from 5:15 to 6:30 p.m. at 137 N. Cottonwood St. in Woodland, featuring UC Master Gardene Steve Radosevich, who will exist bringing worms to give away to participants. The city of Woodland will too exist in attendance to divide free countertop compost buckets for the kitchen. Classes are offered for free throughout the year at the Community Garden.  To learn more about the garden activities and classes, visit www.yolocounty.org/garden. Pre-registration by Oct. 23 is required. To register, contact David Linebarger at 530-666-8429 or [email protected].  Participants are encouraged to dress appropriately for the weather and wear shoes that can accept dirty. In the event of constant rain, the class will exist cancelled.

    * Wednesday, Oct. 24: The Korean Language and Culture Class, meets at 4 p.m. in the Stephens branch Library, 315 E. 14th St. in Davis. This group is for adults who wish to gain a basic lore of Korean language and culture.

    * Tuesday, Oct. 30: Free your body, wit and heart: exhaust your breath with gentle Viniyoga movement and meditations from the Sutra on replete Awareness of Breathing to lower stress and build kindful resilience at Davis Shambhala Meditation Center, 133 D St., from 6 to 7 p.m. on every Tuesday. Drop in or call 415-315-9871 for info.

    * Wednesday, Oct. 31: The Korean Language and Culture Class, meets at 4 p.m. in the Stephens branch Library, 315 E. 14th St. in Davis. This group is for adults who wish to gain a basic lore of Korean language and culture.

    * Sunday, Nov. 4: The Davis Chocolate Festival, organized and hosted by the Davis Odd Fellows Lodge, is back for its third successive year. The event will rush from 3 to 6 p.m. on both floors of the Odd Fellows Lodge, 415 Second St. in downtown Davis. Tickets are $7, available at Avid Reader Active, 605 Second St., at Common Grounds, 2171 Cowell Blvd., and at https://OddFellowsChocolateFest.Eventbrite.com.

    * Thursday, Nov. 6: Sutter freight at Home Hospice offers a Grief and the Holidays workshops in Davis from 6:30 to 8 p.m. Adults who hold lost a loved one and are anticipating having a difficult time at the holidays are invited to this workshop. The workshops are available to complete community members regardless of whether their loved one received hospice care. There is no freight to join. For information and to pre-enroll, call Bereavement Services at 916-388-6215 or 916-388-6243.

    * Wednesday, Nov. 14: Travis Credit Union’s free pecuniary literacy string features “Budgeting for Homeownership” at 6 p.m. in the Blanchard margin at the Stephens branch Library, 315 E. 14th St. in Davis. This seminar presents valuable tips about pitiable and settling into a original house, keeping records, communicating with your lender and creditors, making sure your original home is energy-efficient to save money, taking edge of the pecuniary benefits of owning a home, hiring a contractor if you select to remodel, improving your credit score if you select to refinance and more.

    Related


    Forensic Science Isn’t Science | killexams.com true questions and Pass4sure dumps

    Still photo from CSI. The CSI outcome has led American jurors today to anticipate a constant parade of forensic evidence during trials and to spurn to believe that this evidence might ever exist faulty.

    Photo by Monty Brinton/CBS Broadcasting

    Nine days before death row inmate Earl Washington’s scheduled execution, his lawyers informed the condition of Virginia that it was about to murder an innocent man. Forensic analysis of semen introduced at affliction had convinced the jury that Washington, whose mental abilities matched those of a 10-year-old, had brutally raped and murdered a youthful woman in 1982. Washington’s lawyers uncovered evidence that the analysis was faulty. The condition halted the impending execution, and following a gubernatorial pardon, Washington was released from prison in 2001. He had been there for 17 years.

    Mark Joseph SternMark Joseph Stern

    Mark Joseph Stern covers courts and the law for Slate.

    How could forensic evidence, widely seen as factual and unbiased, nearly ship an innocent person to his death? The retort is profoundly disturbing—and suggests that for every Earl Washington freed, untold more are sent to their deaths. Far from an infallible science, forensics is a decades-long experiment in which undertrained lab workers jettison the scientific manner in favor of speedy results that proper prosecutors’ hunches. No one knows exactly how many people hold been wrongly imprisoned—or executed—due to flawed forensics. But the number, most experts agree, is horrifyingly high. The most respected scientific organization in the country has revealed how deeply, fundamentally unscientific forensics is. A complete overhaul of their evidence analysis is desperately needed. Without it, the number of falsely convicted will only preserve growing.

    Behind the myriad technical defects of modern forensics prevaricate two extremely basic scientific problems. The first is a pretty transparent case of cognitive bias: A startling number of forensics analysts are told by prosecutors what they assume the result of any given test will be. This isn’t mere prosecutorial mischief; analysts often search information from for as much information about the case as possible—including the identity of the suspect—claiming it helps them know what to search for. Even the most upright analyst is liable to exist subconsciously swayed when she already has a conclusion in mind. Yet few forensics labs ensue the typical blind experiment model to liquidate bias. Instead, they reenact a small-scale version of Inception, in which analysts are unconsciously convinced of their conclusion before their experiment even begins.

    The second flaw that plagues forensics is even more alarming: For decades, nobody knew how accurate forensic analyses were, or whether they were accurate at all. There’s no central agency that evaluates each test for precision or reliability before approving its use, and most were developed with barely a gesture toward the scientific manner and with tiny input from the scientific community. Nor did the creators of forensics tests publish their methods in peer-reviewed scientific journals. And why should they? Without a government agency overseeing the field, forensic analysts had no incentive to matter their tests to stricter scrutiny. Groups such as the Innocence Project hold continually Put pressure on the Department of Justice—which almost certainly should hold supervised crime labs from the start—to regulate forensics. But until recently, no agency has been willing to wade into the decentralized mess that hundreds of labs across the country had unintentionally created.

    It might sound astonishing that undependable forensic tests hold been able to slip through the cracks for so many decades. But in light of their inception and use, it’s really no dumbfound at all. Unlike medical diagnostic tools—which undergo rigorous testing by government agencies—forensic analyses are developed exclusively for law enforcement. Almost everybody will exigency a cancer screening some day, but you won’t exigency a semen analysis until you’re convicted of rape. So long as forensics remains the sole province of law enforcement, police and prosecutors hold no incentive to screen their tests for accuracy once they’ve been adopted. Exposing a rank test might connote exposing a wrongful prosecution, and few prosecutors are involved to admit that they might exist sending innocent people to prison.

    The report amounted to a searing condemnation of forensics and a warning that death row may exist filled with innocents.

    In 2009, a National Academy of Sciences committee embarked on a long-overdue quest to study typical forensics analyses with an usurp flat of scientific scrutiny—and the results were deeply chilling. Aside from DNA analysis, not a sole forensic drill held up to rigorous inspection. The committee condemned common methods of fingerprint and hair analysis, questioning their accuracy, consistent application, and generic validity. Bite-mark analysis—frequently employed in rape and murder cases, including capital cases—was matter to special scorn; the committee questioned whether bite marks could ever exist used to positively identify a perpetrator. Ballistics and handwriting analysis, the committee noted, are too based on tenuous and largely untested science. The report amounted to a searing condemnation of the current drill of forensics and an ominous warning that death row may exist filled with innocents.

    Given the flimsy foundation upon which the territory of forensics is based, you might miracle why judges still allow it into the courtroom. The rather depressing retort is a combination of ignorance and laziness. In 1993, the Supreme Court announced a original test, dubbed the “Daubert standard,” to relieve federal judges determine what scientific evidence is dependable enough to exist introduced at trial. The Daubert gauge was meant to separate the judicial process from the quest for scientific truths—but it wound up frustrating judges and scientists alike. As one dissenter griped, the original test essentially turned judges into “amateur scientists,” forced to sift through competing theories to determine what is truly scientific and what is not.

    The Daubert court clearly had tiny understanding of the complex, often contentious affliction and oversight that goes into the establishment of an accepted scientific technique. It instructed judges to search to “the being and maintenance of standards controlling [the technique’s] operation,” a strikingly opaque command tossed off with tiny explanation. Even more puzzlingly, the original standards called for judges to search information from “whether [the technique] has attracted widespread acceptance within a material scientific community”—which, as a frustrated federal referee pointed out, required judges to play referee between “vigorous and wholehearted disagreements” about “the very cutting edge of scientific research, where fact meets theory and certainty dissolves into probability.”

    Faced with this unenviable chore, most judges hold simply trusted prosecutors not to interlard anything that wouldn’t roughly proper the Daubert standard. The conventional wisdom is that, if a prosecutor introduces any truly egregious pseudoscience, the defense can interlard its own expert to refute it or can undermine it through aggressive questioning. It’s a comforting idea: Presented with conflicting scientific findings, jurors will sift out the truth.

    Unfortunately, it is too entirely false. American jurors today anticipate a constant parade of forensic evidence during trials. They too spurn to believe that this evidence might ever exist faulty. Lawyers call this the CSI effect, after the celebrated procedural that portrays forensics as the ultimate verity in crime investigation.

    “Once a jury hears something scientific, there’s a benevolent of mythical infallibility to it,” Peter Neufeld, a co-founder of the Innocence Project, told me. “That’s the association when a person in white lab coat takes the witness stand. By that point—once the jury’s heard it—it’s too late to convince them that maybe the science isn’t so infallible.”

    If judges can’t exist trusted to preserve spurious forensic analysis out of the courtroom, and juries can’t exist trusted to disregard it, then how are they going to preserve the next Earl Washington off death row? One option would exist to permit anybody convicted on the basis of biological evidence to matter that evidence to DNA analysis—which is, after all, the one figure of forensics that scientists accord actually works. But in 2009, the Supreme Court ruled that convicts had no such constitutional right, even where they can expose a reasonable probability that DNA analysis would prove their innocence. (The ruling was 5–4, with the customary suspects lining up against convicts’ rights.)

    That leaves one eventual option: reforming the sprawling territory of forensics itself. For years, this job proved nearly impossible, due in large allotment to what the National Academy of Sciences called the “extreme disaggregation” of forensics. Until lab technicians ensue some uniform guidelines and abandon the dubious techniques glamorized on shows dote CSI, forensic science will barely qualify as a science at all. As a recent investigation by Chemical & Engineering advice revealed, tiny progress has been made in the five years since the National Academy of Sciences condemned modern forensic techniques.

    There is, however, some hope on the horizon. The Obama administration has started to aggregate forensics practices, creating a National Commission on Forensic Science to develop uniform standards to exist used across the country. The National Institute of Justice has too given out more than $100 million to fund research into the efficacy and consistency of commonly used forensics techniques.* More and more, labs across the country will know which methods of forensic analysis are trustworthy—and which are glorified pseudoscience.

    But what about those thousands of people who’ve already been Put behind bars based on evidence analysis that they know today to exist utterly unreliable? Even those inmates fortunate enough to obtain capable counsel will often exigency access to biological evidence, which the Supreme Court has refused to vouchsafe them. Every condition provides post-conviction DNA access in theory, but many states restrict access after a few years—which is sure to leave some innocent prisoners marooned on death row. Their national experiment in untested forensics may soon exist coming to a close. But it hasn’t ended in time to prevent a few more people dote Earl Washington from being sacrificed on the altar of pseudoscience.

    *Correction, June 11, 2014: This article originally understated the amount of funding the National Institute of Justice has distributed for research on forensic techniques. (Return.)



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