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920-131 Symposium Express Call Center Inst and Maint

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920-131 exam Dumps Source : Symposium Express Call Center Inst and Maint

Test Code : 920-131
Test Name : Symposium Express Call Center Inst and Maint
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Nortel Symposium Express Call Center

iMessaging Integrates i OS software with Nortel name center application | killexams.com Real Questions and Pass4sure dumps

organizations that use the Symposium name core application from Nortel now have a less complicated solution to achieve integration with i OS purposes. ultimate week, iMessaging options announced a kit of application and features that makes it possible for its encourage telephony utility to integrate with Symposium.

Nortel bills its Symposium name core Server as an advanced and scalable platform for automating the distribution of incoming calls in a contact core. The application makes groups greater effective by guiding callers via a “mobile tree” to verify the goal of a call, and then routing the name to the consumer service representatives (CSRs) with the appropriate expertise.

It’s commonplace for Symposium clients to pressure even more automation into their call core operations by way of integrating their call core software with enterprise functions. This offers benefits, such because the potential to right now pull up suggestions, like client facts, before routing the call to the applicable CSR.

youngsters, integrating mobilephone systems with company applications is notoriously complex, and requires huge customization capabilities. but on account of iMessaging’s new inspire for Symposium providing, Nortel valued clientele can connect their Symposium methods to i OS functions, whereas leveraging the wide journey that iMessaging has during this container of contact center operations.

the brand new providing supplies two basic merits, in accordance with iMessaging. First, the combination enables the Symposium system to convey customized display “pops” to the workstations of CSRs. These reveal pops can also be a display from nearly any i OS utility, and supply CSRs with brief access to records from core company purposes. It additionally eliminates the need for CSRs to manually navigate throughout the i OS software to get to the vital screen.

The second advantage is the delivery of interactive voice response (IVR) capabilities that permit callers or call recipients to engage with business purposes over the cellphone, the usage of both voice cognizance or the phone’s keypad. encourage can carry IVR performance to Symposium for each inbound and outbound calls, iMessaging says.

moreover the encourage application, iMessaging’s new answer contains mission administration, implementation, configuration, and building capabilities. The solution begins at about $20,000. iMessaging is offering prospective clients free 30-minute assessments. For more tips, discuss with www.imessagingsolutions.com.

connected studies

iMessaging and IBM group to power i OS-based IP Telephony

iMessaging Adopts SIP for call core software

iMessaging promises a manager’s View into name center activity

iMessaging provides Outbound Dialing to encourage name middle Suite

iSeries-centric name middle Suite Renamed encourage

iMessaging Boosts help for Spanish in Interactive Voice system

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The 2005 CRM service Leaders--half I | killexams.com Real Questions and Pass4sure dumps

The editors respect the proper-three leaders in CTI, IVR, great monitoring, net self-carrier, group of workers administration and optimization, contact-middle outsourcing capabilities, and agent-dealing with frequent desktop applications. The service Leaders rankings are derived from a weighted formula that includes monetary efficiency in addition to analyst ratings for depth of functionality, acceptance for consumer delight, and corporate and management course.

Edited by means of David Myron

click here to view chart.

computing device Telephony IntegrationThe MarketThe phone continues to be essentially the most normal approach for consumers to contact an organization, but some distance be it from a call core manager to discourage individuals from the use of a much less costly capability of contact just like the internet or electronic mail. average computer telephony integration (CTI) methods are enabled through a complex-but-functional public switched cell network, however more contact middle managers are considering the fact that Voice over IP (VoIP), which offers a single company information community for all customer verbal exchange wants.

VoIP cuts telephone charges by using transmitting voice indicators in packets over deepest or public networks by way of the web Protocol, obviating the need for separate telephone circuits. This offers three fundamental advantages to consumer organizations: reduce cost, much less complexity, and the capability to create a digital call center where brokers can work at home. whereas all the leaders within the CTI space have typical circuit-switched options, all of them have mighty VoIP choices, as well.

The LeadersA reasonable score of three from analysts surveyed in the enterprise path category weighed on Avaya's capability to declare the good spot. concerning interoperability with other vendor items, Bernard Elliot, research enviornment leader for contact centers at Gartner, says, "there's restrict with what that you could do with them--Avaya does Avaya." still, if you are in the Avaya environment, odds are you are reasonably satisfied. No other CTI supplier got here close to Avaya's client delight score of four.2, in response to analysts polled.

Avaya's CTI providing comes as part of its customer interplay Suite, which extends its predictive routing know-how to email and the web, attainable in both circuit-switched and IP-based environments. options during this suite scale from the Avaya IP workplace, proper for small name centers, to its S8700 platform for prime-volume facilities.

Nortel Networks edged out Cisco systems on the listing of CTI leaders this yr, however remains going through some difficulties largely due to its fiscal woes. "Nortel appears to be slowly fading from the market as their monetary difficulties crush their product offerings. The low-conclusion portfolio, company Communications manager (BCM), with its focal point on IP telephony, has made it simpler for call centers to installation CTI--the equal can not be referred to of the better end Succession products," says David Peterson, president of PowerHouse Consulting.

Nortel tied Avaya for the lowest ranking of 3 in business course, and tied Cisco for the bottom rating of 3 intensive of performance, in response to analysts polled. keeping it among the many leaders, besides the fact that children, is its ranking of 3.three in customer delight, besting Cisco's low rating of two.eight.

Nortel offers circuit-switched, IP-enabled, and IP-based products for small-and-medium business with its Symposium specific and BCM, and for greater groups with its Symposium name center product line.

The WinnerGenesys Telecommunications Laboratories, a wholly owned subsidiary of Alcatel, tops the CTI checklist for the second yr in a row. remaining 12 months, Genesys got high marks for its integration capabilities--and this year is not any diverse. customers can purchase preintegrated plug-ins for smoother integration into different name middle purposes from carriers like Oracle, PeopleSoft, SAP, and Siebel.

not fantastically, its scores in each company route and depth of functionality topped the charts with a 4.5 in every, in line with analysts polled. "they are the only 1 who definitely sells the stuff," Elliot says, including that opponents are selling CTI options as a hook to promote other call middle items.

Genesys has improved its client interplay management Platform to enhance help for multivendor networking VoIP, and requirements like Session Initiation Protocol. The platform allows for interactions via common voice, VoIP, e mail, and web chat. --David Myron

CTI One to WatchAlthough Cisco is the clear winner in the TCP/IP infrastructure market, the business nevertheless lags at the back of CTI opponents extensive of functionality. What subsequently bumped Cisco off the leader checklist become its low score of 2.eight in client satisfaction, in keeping with analysts polled. Cisco obtained the 2d maximum ranking (behind Genesys) among analysts for enterprise course, with a 3.2, but business pundits wish to see extra depth to its product line. "Cisco has a protracted subculture of including CTI performance within the epidermis of their call middle portfolio. The susceptible hyperlink in the Cisco delivery chain is the inconsistent efficiency of their [value added reseller] community," says David Peterson, president of PowerHouse Consulting --D.M.

Interactive Voice ResponseThe MarketSpeech options can act as a way to help alter the paradigm that contact middle managers are by no means-endingly faced with: migrating valued clientele who call in to contact centers with basic consumer inquiries like checking account balances to more reasonably-priced channels like an interactive voice response (IVR) device. despite the fact these options can drastically diminish expenses, agencies had been locked in to companies. Open necessities like VoiceXML and Speech software Language Tags (SALT) are liberating conclusion clients and allowing more recent players like BeVocal, TuVox, and VoiceGenie technologies to throw their hats into the ring. These more recent youngsters on the block don't seem to be the largest dots on the radar monitor, however they are turning heads. For now, although, they flip their consideration to one of the most greater ripe vendors. competitors is tight: In a primary for CRM magazine's carrier awards, two agencies tied as winners in a category.

The LeaderIt's been a bumpy cycle financially for Nortel Networks: The company is carrying on with to work on the restatement of its monetary results for prior quarters. still, even Nortel's estimated unaudited revenues for simply the 2nd half of 2004 of about $5.1 billion are more than double the profits of its closest competitor within the house for the whole year. obviously a dominant presence, the business presents a large-ranging product portfolio of self-provider solutions. Its Nortel Self-service systems (previously Periphonics Self-provider systems) includes its Media Processing Server (MPS) one hundred, MPS 500, MPS one thousand, and Voice Processing collection/assistance Server, with MPS 500 and MPS a thousand, including VoiceXML. "Periphonics had lots of market penetration when Nortel purchased them," Peterson says. "They moved very promptly into the IP area, [but] Nortel could be dragging them down with all their fiscal issues."

The company launched its web-Centric Self-carrier answer in 2004, which additionally uses open business standards. however not all analysts are impressed. "They had been late with VoiceXML compared to one of the other guys," says Sheila McGee-Smith, president and fundamental analyst of McGee-Smith Analytics, and "[they] have a muddled story with MPS and net-Centric Self-service." nonetheless, Nortel Networks' attain remains felt. Gartner placed the company as a pacesetter in its Magic Quadrant for IVR and enterprise Voice Portals for 2004.

The WinnersCall them the new England Patriots of the IVR enjoying field. closing year's category champion, Avaya, reeling in $4.1 billion in revenues for fiscal 12 months 2004, compared to 2003's $three.8 billion, has reclaimed its throne for the second 12 months in a row. After gaining momentum within the IVR space with its Conversant application and now with its Avaya Interactive Response solution, Avaya managed to record strong marks from their analyst ballot in each company course and reputation for customer satisfaction, despite the complications that some clients may additionally have skilled migrating from a Conversant platform to an IR platform. "They misplaced shoppers because they didn't really control the method smartly," McGee-Smith says, but, "they've got a nice full product portfolio in contact middle [solutions], and the IVR [ties] into that smartly." The enterprise's ammunition includes Avaya Contact center specific, a multimedia contact core solution designed particularly for midsize corporations, and the Avaya Speech functions Builder, enabling developers to design speech automation services the use of open specifications (together with VoiceXML). Avaya and IBM announced that they'll convey speech-enabled self-provider solutions, combining the previous's IP-based contact center application for self-provider with the latter's WebSphere infrastructure utility. And the company's billion-dollar decision? buying Tenovis GmbH & Co. KG, a provider of business communications systems and services, in a deal if you want to require Avaya to pay about $370 million in cash and tackle about $265 million in debt. When entirely integrated, although, Avaya expects the acquisition so as to add approximately $1 billion to its annual revenues.

Avaya shares the highlight with remaining 12 months's second runner-up, Intervoice. youngsters its earnings barely compares with that of its lots greater rivals (for the 4 quarters achieved November 30, 2004, Intervoice amassed $178.1 million, in comparison to its old 4 quarter earnings of $one hundred sixty million), the company managed to outscore each Avaya and Nortel for its recognition of client pride and its functionality. It was just a couple of tenths of some extent far from perfect rankings in each classes. "The undeniable fact that that you could host it or purchase the application your self works out well for a lot of valued clientele, as a result of they may--specially for speech applications--need to birth out with a hosted software after which carry it in-condo," says Elizabeth Ussher, a vice president at META neighborhood. Intervoice's Omvia Voice Framework, which the company claims is probably the most open voice answer product available on the market, helps a traditional, VoiceXML, or SALT environment. both the Omvia Voice Framework and its Voice specific packaged functions help Microsoft Speech Server 2004. --Coreen Bailor

IVR One to WatchWell customary for its CTI capabilities, Genesys Telecommunications Laboratories isn't a general suspect in the IVR world. nonetheless, in 2002 Genesys purchased Telera, a VoiceXML options company, an acquisition analyst Sheila McGee-Smith describes as "a bounce-frog flow" for the Alcatel subsidiary. And in 2004 the business unveiled its Genesys Voice Platform: Developer edition, a construction device for building VoiceXML 2.0-based functions. It also announced a partnership with IBM to carry enterprisewide speech-enabled self-provider options via a suite of WebSphere speech capabilities built-in with Genesys Voice Platform. "they are engaged on things which are highway mapped for 2005, however as they stand right here right now, they're no longer there yet," McGee-Smith says. but, "they are on the right route." --C.B.

quality MonitoringThe MarketThe fine monitoring (QM) market is at a pivotal aspect in its evolution. QM tools checklist consumer interactions to ensure that first-rate degrees are being met, and can help managers maintain music of agents' performances, while spotting problem areas that can be enhanced with e-studying options. providers in the space, although, trying to extra their attain and break away from the pack, are moving into the business with either product enhancements or acquisition strikes. "The a success vendors, going forward, should be those that understand that first-rate monitoring is just one factor on the map," says Ken Landoline, vice chairman and major analyst at Saddletree analysis. "They actually need to expand into the full breadth of a set of items that is going to optimize overall enterprise performance within the business." in the QM and group of workers management markets that are, in keeping with Jim Davies, predominant analyst at Gartner analysis, at least 60 % penetrated, this year's QM leaders took steps to keep up with this style and their competitors.

The LeadersWith its solid 13 percent profits boom great systems continues its position as a leader within the QM enviornment, regardless of its just a little beneath-regular (but nonetheless strong) ranking for popularity for client satisfaction. nonetheless, analysts had been most impressed with excellent's platform, awarding the company larger marks for performance than every other seller within the area. The 2004 class champion's free up of first-rate operate illustrates the business's skill to extend past the contact middle market and movement into the business as a whole. "They've realized the name center QM market is starting to turn into a little saturated," Davies says. "taking a look at their approach, they are trying to get into other customer-facing departments inside the organization by leveraging the connection they already have with the name core. They are trying to drive their recording, contrast, and analytical utility into these other departments to positively have an impact on the performance of the enterprise as an entire."

The business, through achieving into the security market and capitalizing on its channel partnerships, is hoping to prolong its attain. "What fine has carried out well is twofold...having a various portfolio of items--protection, logging, and quality monitoring--and...benefiting from being in the correct business at the appropriate time," says Carole Macpherson, senior program director at META group. "great has also leveraged a robust partnership channel (e.g., Avaya) and has secured offers in keeping with these gigantic manufacturers." If satisfactory continues to movement greater into the enterprise by way of product building or perhaps even an acquisition, look for the $252.6 million business to have a robust probability at reclaiming its crown.

Our old 12 months's runner-up, Verint, is steadily nipping on the heels of its competitors, even whereas receiving the category's lowest marks for company course. definitely, based on some business insiders, the business has gotten tons less aggressive in its method. "The enterprise is more concentrated on the call center and appears to distinguish itself through superior analytical perception," Davies says. "youngsters, their analytical center of attention for the protection and BI markets does tend to mask their QM product line. I have not actually seen them do an awful lot from an integration [or] mergers/acquisitions standpoint," he says. then again, Verint's effective numbers for each its performance popularity and reputation for consumer delight, and its astonishing 27.7 p.c earnings increase during the last 4 completed quarters, helped to keep its in-the-appropriate-three repute.

The WinnerMaking the category's largest jump from last yr's rankings, due generally to its progressive imaginative and prescient, is remaining year's third-region finisher, Witness systems. regardless of its third-vicinity rating for its recognition for depth of functionality, Witness outperformed all class contenders in reputations for each consumer delight and company route. in fact, the company delivered more than 200 client wins to its client base, while boasting a customer retention ranking more advantageous than ninety five % for 2004, which may additionally assist account for its $141.3 million in total income, an brilliant 30.eight percent increase over 2003's tally. And, in accordance with Paul Stockford, chief analyst of Saddletree analysis, the enterprise's acquisition of workforce administration vendor Blue Pumpkin positions the combined business because the market chief in developing an integrated staff optimization answer.

Macpherson agrees: "Witness leaves behind a fragmented and specialized market with over 25 carriers that present one or two items of a [production value management] suite and enters into a new arena with fewer competitors." other than the acquisition, Witness more advantageous its solution capabilities, together with extending its eQuality utility to improve the productiveness of returned-office functions like order achievement and billing, with eQuality workplace.eQuality office permits agencies to trap worker computer actions, evaluate recorded transactions, region sample recordings in touch folders for certain company services, and establish most efficient practices, enabling clients to edit recorded transactions to create e-getting to know solutions. The burning difficulty, despite the fact, is how well Witness can integrate with Blue Pumpkin. That nevertheless remains to be viewed, so one can obviously make 2005 a memorable yr for Witness. --Coreen Bailor

quality Monitoring One to WatchAlthough Envision is a appreciably smaller enterprise than their bigger class leaders, the business introduced 50 new purchasers to its roster, including Canon, IKEA, and ShopNBC, and retained 99 p.c of its existing customers, making it their One to watch. consistent with the style of evolving to group of workers optimization, Davies says that Envision already offers a QM and WFM answer from a single platform, "however there's an extended way to go before any dealer offers a complete unified answer conceivable for significant, complex groups." because it's a small, aggressive dealer, Carol Macpherson, META group analyst, says, "they are going to are usually bendy on pricing and intensely responsive on servicing shoppers." If it continues to build its company loyalty, upcoming years may encompass a brand new addition to the leaderboard. --C.B.

net Self-ServiceThe MarketFor a decade organizations have struggled to make their web presence act as greater than brochureware. creating intelligent, informative, and obtainable portals for consumer provider has long been a prime purpose of many agencies, and it is simply now that wholly built-in content development, database storage, and search-and-retrieval methods are starting to come into alignment to deliver a self-provider adventure it really is a meaningful alternative for a significant portion of internet users--an ever-growing population. The leaders in this area have, no matter if via aggressive acquisition or grass roots growth, dependent themselves as serious practitioners and suppliers of least expensive, high-effectivity provider options for digital consumers and business patrons.

The LeadersATG (together with recent acquisition Primus) has broad event providing solutions to various issues businesses want their on-line presence to clear up. The commerce-concentrated ATG bought an quick raise by picking out up Primus's enormously regarded potential base and customer-dealing with capabilities. that is the first rate news. The dangerous information is that the year forward can be a difficult one for ATG, because it have to rationalize Primus, itself the fabricated from dissimilar acquisitions, and convey a coherent self-carrier product to market. "The one component i might ding them on now could be that they have got 5 distinctive [self-service] systems...a couple of issues ATG become engaged on, and Primus has at least three different platforms," says Allen Bonde, president of analysis enterprise ABG.

The pairing has failed to increase on Primus's middling reputation for consumer satisfaction, which hurt the business's ranking ultimate 12 months and, left unchecked, may push ATG off their leaderboard wholly. internet self-service is still an emerging market with a few distinct styles and strategies, and no single company has yet confirmed itself to be essential.

KANA has stayed the route of its latest reinvention to turn into an information and service professional. final yr's class winner doesn't appear to have made any essential missteps and continues to combine and construct out its self-service offerings. "Their expertise has been around a long time...however they are confirmed as a self-provider company," Bonde says. one of KANA's largest accomplishments in the self-provider area became securing the services of former Primus CTO Charles Isaacs after the ATG acquisition. within the same role at KANA, the abilities management veteran may still drive KANA's know-how vision for some time. look ahead to KANA to further enrich its prebuilt integration with different business software programs.

The WinnerRightNow technologies turned into simply an up-and-comer ultimate year, but an outstanding one year of boom, a successful public offering, and high marks from valued clientele make it this 12 months's class winner. RightNow's key to success? "They promote neatly as a result of they clear up complications for people," Bonde says. The on-demand talents bases the company gives have confirmed intuitive to deploy and keep for strapped guide businesses, and have been acquired neatly ample by valued clientele to make the subscription model ring up satisfied returns for RightNow.

What RightNow isn't is the most powerful and feature-stuffed self-service solution available on the market--but rather often, technical dominance and market success are two very different things. "we've got dinged them on the know-how, however they have been fantastic when it comes to execution and recognition," Bonde says. "Greg [Gianforte, RightNow CEO] would disagree, but they consider they may add extra search potential and extra management capability."

For RightNow to continue to be a class leader, it's going to should evolve with a growing to be number of fascinated customers. "Their FAQ strategy to the realm is [best] within the high-extent CPG trade, which is the place they do well...however they have only 1 look-and-suppose, and also you recognize immediately in the event you are on a RightNow website as a result of they all look alike," says Forrester vp John Ragsdale. --Jason Compton

web Self-service One to WatchAlthough the busy self-service space has a couple of promising contenders, together with the merged Kanisa/ServiceWare and everyday search professional iPhrase, Siebel's late-2004 buy of edocs invokes the historical 800-pound gorilla rule--if it's relocating, one had most excellent take heed. Edocs has constructed a acceptance for prime-quantity, totally advanced engagements that can also seem to be more like bitter drugs than a joy for all concerned, however more important, the enterprise become generally credited with getting the job done. Siebel gets an instant enhance to its self-help providing, and can not be performed constructing its capabilities. "i'm satisfied Siebel has as a minimum yet another acquisition to do in this space," says ABG's Allen Bonde. --J.C.

click here to examine The 2005 carrier Leaders--part II.


Avaya's New Route for subsequent-Gen purchasers | killexams.com Real Questions and Pass4sure dumps

February 08, 2010

through Brendan B. read Senior Contributing Editor

there's a brand new era of purchasers that's rising on the marketplace, one it is empowered and which have taken control of the interactions, armed with potential about the organizations and their offerings, equipped by the use of social media to make or wreck establishments’ reputations. they're disturbing that the organizations they engage with carry to them by the use of a widening array of channels of their alternative: voice, internet, chat, electronic mail, SMS, social media and video the counsel, items and services right now.

 

Avaya is now building and will start opening later this year a new path to support groups to lift this new generation plus by using likeminded older purchasers by means of the contact centers. the new parkway is the Avaya next Gen Context middle Portfolio for the contact center market, in order to relaxation on the Avaya charisma SIP-primarily based communications platform. The keyword right here is “context.” The firm says next technology context-primarily based consumer service is the ability to streamline suggestions, tactics and communications to deliver a consistent, excessive-cost end-customer engagement. this could subsequently supply consumers with the sophisticated service adventure they are demanding.

 

Avaya unveiled the toll road Jan. 19 with its “Roadmap for way forward for company Communications,” which integrates its items with those from the former Nortel business options. Avaya acquired the division from the bankrupt communications machine firm at auction in 2009 for $915 million.

 

the key guideposts of the Avaya subsequent Gen Context core course consist of watching for consumer wants with proactive multichannel notification options and effectively automating voice and internet self-provider interactions by means of communications enabled company programs. They also include accelerating productiveness goals via optimizing agent, skilled, self-provider interactions throughout channels for effective operations.

 

“We’re focused on fixing the subsequent generation customer care challenge, which requires the delivery of holistic, seamlessly-linked services for a generation of valued clientele that expect to acquire care in numerous different ways,” says Jorge Blanco, Avaya vp, contact center product advertising and marketing. “we now have also been focused on how we’re going to harness all types of assistance both realtime and non realtime and give way them onto the client care technique. The plan they have developed is extensible and includes all communications channels.”

 

The Nortel acquisition has brought considerably to the engineering ability, tools and the raw materials for the Avaya next Gen Context core route, as a way to aid contact facilities get where they want to go faster, with fewer bumps and with better efficiency.

 

Avaya plans to leverage key features from the Nortel contact middle suite including media managing and workforce applications, plus some of the one of the crucial views and supervisory capabilities reminiscent of agent stat views from Nortel’s desktop application. Avaya is incorporating the Nortel Agile communique ambiance (ACE), which is an open application platform for constructing multi-seller communications-enabled enterprise strategies and unified communications functions into the Avaya air of secrecy solution.

 

“What we’re trying to do with both the Avaya and Nortel products is to make certain that their most inventive aspects and capabilities are included in the subsequent Gen Context core,” says Blanco.

 

at the identical time the Avaya roadmap is including onramps for current Nortel shoppers that will movement without difficulty and gradually onto the brand new thoroughfare. Avaya has a common product guide policy of six years beginning with manufacturers’ and then adding non-compulsory extended guidance. house owners of Nortel contact center products akin to Symposium express could have loads of time to make the turn onto the next Gen Context middle.

 

Avaya can be blending contact center call recording, reporting, and exceptional administration capabilities of Nortel line with its own name administration, recording and QA systems into the next Gen portfolio. groups have constructed their businesses across the reporting engines that they run, and might unwell-manage to pay for to have them modified without seamless migration capabilities, explains Blanco.

 

similarly Avaya is meshing Nortel’s IVR and speech recognition options by means of the Avaya Voice Portal. There are tons of of heaps of such applications that Avaya and legacy Nortel customers have deployed in combination on these systems, that are very scalable, stories Blanco, and which the firm isn't looking to disrupt presently.

 

“we are how those purposes can be transitioned to the subsequent Gen ambiance over time,” says Blanco. “That’s what their shoppers expect.”

Brendan B. read is TMCnet’s Senior Contributing Editor. To study more of Brendan’s articles, please seek advice from his columnist page.

Edited by using Erin Harrison


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Oklahoma Gardening School, 'Growing Beautiful, Successful and Low-Maintenance Herb Gardens' | killexams.com real questions and Pass4sure dumps

Published: Sat, February 23, 2019 5:00 AM

Oklahoma Gardening School at Myriad Botanical Gardens, the annual horticultural symposium for home gardeners and professional horticulturists, garden designers and landscape architects, will be from 9 a.m. to 4 p.m. March 9 at Devon Auditorium, 333 W Sheridan Ave., just west of Devon Energy Tower.

The theme of the symposium, presented by the Meinders Foundation and Devon Energy, is “Growing Beautiful, Successful and Low-Maintenance Herb Gardens.”

Guest speakers will demonstrate, through illustrated talks and mp;A discussions, how to grow herb gardens through adaptive designs, proper plant selection, and precise cultivation and maintenance practices.

Sponsors include TLC Garden Center, Grooms Irrigation, American Plant Products, Calvert’s Plant Interiors, Kitty and Richard Champlin, Minick Materials, Total Environment and Plant Wisdom Garden Center. In-kind sponsors are AC Hotel by Marriott OKC Bricktown and Holiday Inn Express-Bricktown.

Cost is $40 for Gardens members, $70 for nonmembers and $25 for students (with ID). Optional box lunches can be purchased for $15. Lunch will be in the Park House Event Center at Myriad Gardens where an Herb Market will be presented by Bill Farris, owner and operator, of Prairie Wind Nursery in Norman. Register at myriadgardens.org. For more information, call 445-7080.

Speakers will be:

• Matthew Benson, Balmville, New York, a writer, photographer, author and organic farmer whose work focuses on issues of food, sustainability, and organics. He is the owner of Stonegate Farm in New York’s Hudson River Valley, where he cultivates organic vegetables, historic fruit, raw honey, and medicinal flowers and herbs. His farm has been featured in The New York Times, Better Homes & Gardens, Organic Gardening and the television show "This Old House," among others.

• Holly Shimizu, Glen Echo, Maryland, a nationally recognized horticulturist with a specialty in herbs and herb gardens. She was the first curator of The National Herb Garden at the U.S. National Arboretum in Washington, D.C., executive director of the U.S. Botanic Garden, and for more than 10 years was a host of the popular "Victory Garden" on PBS.


Wave Life Sciences Announces Suvodirsen Phase 1 Safety and Tolerability Data and Phase 2/3 Clinical Trial Design | killexams.com real questions and Pass4sure dumps

April 16, 2019 07:00 ET | Source: Wave Life Sciences

Data to be presented today at 2019 Muscular Dystrophy Association Clinical and Scientific Conference

Phase 2/3 clinical trial for suvodirsen in DMD expected to initiate in July 2019

Interim efficacy data from ongoing open-label extension study expected in H2 2019

Investor conference call scheduled for 7:30 a.m. ET today to discuss Phase 1 results and Phase 2/3 trial design

CAMBRIDGE, Mass., April 16, 2019 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (NASDAQ: WVE), a clinical-stage genetic medicines company committed to delivering life-changing treatments for people battling devastating diseases, today announced the final results from its Phase 1 clinical trial of investigational suvodirsen (WVE-210201) in boys with Duchenne muscular dystrophy (DMD) who are amenable to exon 51 skipping. The company also announced the design of its planned Phase 2/3 clinical trial of suvodirsen in DMD, DYSTANCE 51. The Phase 1 data and DYSTANCE 51 details will be presented today at the 2019 Muscular Dystrophy Association (MDA) Clinical and Scientific Conference in Orlando, Florida.

“We are delighted that suvodirsen's Phase 1 results demonstrate a favorable safety and tolerability profile that allow us to proceed rapidly into Phase 2/3 clinical development with doses they expect to be within the therapeutic window. Later this year, they expect to report interim efficacy data from the ongoing open-label extension study of suvodirsen and intend to use those data as an important component of a submission for accelerated approval in the United States,” said Michael Panzara, MD, MPH, Chief Medical Officer of Wave Life Sciences. “We truly appreciate the boys and families that made this trial possible.”

Phase 1 Clinical Trial ResultsWave’s Phase 1 clinical trial was a global, multicenter, double-blind, placebo-controlled study designed to evaluate the safety, tolerability and plasma concentrations of single ascending doses of suvodirsen administered intravenously. Thirty-six patients received a dose of 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg, 7 mg/kg or 10 mg/kg of suvodirsen (n=26) or placebo (n=10) in five ascending dose cohorts and were followed for 85 days. No serious adverse events, deaths or discontinuations due to adverse events were reported in any study patients treated with suvodirsen.

In December 2018, the company selected an initial dose for the DYSTANCE 51 Phase 2/3 clinical trial based on results from the first four cohorts (0.5 mg/kg – 5 mg/kg) of the Phase 1 clinical trial. Key findings from suvodirsen patients in those four cohorts (n=24) and all placebo patients (n=10) include:

  • Suvodirsen was generally safe and well tolerated;
  • 67% of patients who received suvodirsen (16/24) and 80% of patients who received placebo (8/10) experienced one or more adverse events;
  • The most common adverse events occurring in two or more patients who received suvodirsen were pyrexia, headache, vomiting and tachycardia, consistent with infusion-associated reactions;
  • Adverse events in patients receiving suvodirsen were mild to moderate in intensity and resolved spontaneously or with symptomatic treatment;
  • No clinically relevant changes were observed in renal or hepatic parameters or platelet levels;
  • In patients receiving 5 mg/kg of suvodirsen, the adverse events that occurred within 24 hours of infusion were associated with transient increases in high-sensitivity C-reactive protein and complement factor Bb levels, both of which were resolved within a week; and
  • No changes were observed in complement C3 levels.
  • Based on results of the first four ascending dose cohorts, the independent Safety Monitoring Committee of the Phase 1 clinical trial endorsed continued dose exploration by proceeding to the last planned cohort. Doses of 7 mg/kg or 10 mg/kg of suvodirsen were administered to two patients in the fifth cohort and were associated with similar adverse events as those observed at lower doses but were more severe in intensity. The full data from the Phase 1 clinical trial will be presented in an oral presentation and poster at today’s MDA conference.

    “The safety profile of suvodirsen observed in this study is encouraging and supports continued progression to a Phase 2/3 study,” said Kathryn Wagner, MD, PhD, chair of the suvodirsen clinical advisory committee and director of the Center for Genetic Muscle Disorders at the Kennedy Krieger Institute at the Johns Hopkins School of Medicine. “These data, along with Wave’s innovative approach to chemical design and clinical development, make me optimistic about suvodirsen’s potential as a possible DMD treatment.”

    Design for Phase 2/3 DYSTANCE 51 Clinical TrialIn a second poster, Wave will present the design of DYSTANCE 51, a global, multicenter, randomized, double-blind, placebo-controlled Phase 2/3 efficacy and safety clinical trial of suvodirsen in DMD patients amenable to exon 51 skipping. This clinical trial is designed to enroll boys who are between 5 and 12 years of age (inclusive) with a genetically confirmed diagnosis of DMD amenable to exon 51 skipping therapy. Patients will be randomized to receive 4.5 mg/kg or 3 mg/kg of suvodirsen or placebo administered intravenously once weekly for 48 weeks. The 4.5 mg/kg dose in DYSTANCE 51 provides approximately the same amount of active ingredient as the 5 mg/kg dose in the Phase 1 clinical trial. Both doses have been selected based on the Phase 1 clinical trial results as well as data from in vitro and in vivo nonclinical studies.

    The DYSTANCE 51 primary efficacy endpoints will measure change in dystrophin protein level and change in the North Star Ambulatory Assessment score. In addition, this Phase 2/3 clinical trial will include multiple functional outcome measures as secondary efficacy endpoints. DYSTANCE 51 is expected to be initiated in July 2019 and the company intends to use the results of this trial to seek regulatory approvals globally.

    Earlier this year, Wave announced that the DYSTANCE 51 clinical trial was selected for the U.S. Food and Drug Administration (FDA) pilot program for complex innovative trial designs. As a participant in the pilot program, the company has additional opportunities to meet with FDA staff to discuss the design elements of the trial, including the potential use of Bayesian methods to adapt the trial with the aim of allowing for more efficient and productive clinical determinations.

    Ongoing Open-label Extension StudySuvodirsen is currently being studied in an ongoing, multi-dose, open-label extension (OLE) study initiated in August 2018 with patients from the Phase 1 clinical trial. The company expects to report an interim analysis of dystrophin expression from muscle biopsies in boys receiving suvodirsen in the OLE study in the second half of 2019. Data from this analysis are intended to serve as an important component of a submission to the FDA for accelerated approval.

    Investor Conference Call and WebcastWave management will host an investor webcast and conference call today at 7:30 a.m. ET to discuss the Phase 1 safety and tolerability results of suvodirsen, as well the design of the DYSTANCE 51 Phase 2/3 clinical trial. The conference call may be accessed by dialing (866) 220-8068 for participants based in the United States. or +1 (470) 495-9153 for participants based outside the United States and entering conference ID 8975967. The accompanying slide presentation and live webcast may be accessed by visiting the investor relations section of the Wave Life Science corporate website at www.ir.wavelifesciences.com. Following the webcast, a replay will be available on the website.

    About Duchenne Muscular Dystrophy

    Duchenne muscular dystrophy (DMD) is a fatal X-linked genetic neuromuscular disorder caused predominantly by out-of-frame deletions in the dystrophin gene, resulting in absent or defective dystrophin protein. Dystrophin protein is needed for normal muscle maintenance and operation. Because of the genetic mutations in DMD, the body cannot produce functional dystrophin, which results in progressive and irreversible loss of muscle function, including the heart and lungs. Worldwide, DMD affects approximately one in 5,000 newborn boys.

    About Suvodirsen (WVE-210201)

    Suvodirsen is an investigational stereopure oligonucleotide that has been shown to induce skipping of exon 51 of dystrophin pre-mRNA in preclinical studies and is intended for the treatment of Duchenne muscular dystrophy (DMD). Approximately 13% of DMD patients have genetic mutations that are amenable to treatment with an exon 51 skipping therapy. Exon-skipping technology has the potential to induce cellular machinery to ‘skip over’ a targeted exon and restore the reading frame, resulting in the production of internally truncated, but functional dystrophin protein. Wave preclinical in vitro experiments using gymnotic delivery (free uptake) of suvodirsen in DMD patient-derived myoblasts demonstrated efficient exon 51 skipping and dystrophin protein restoration. Preclinical Western blot studies of suvodirsen demonstrated 52% dystrophin protein restoration compared with normal skeletal muscle tissue lysates. Suvodirsen has been granted orphan drug designation for the treatment of DMD by the U.S. Food and Drug Administration (FDA) and the European Commission, as well as rare pediatric disease designation by the FDA. In addition, the planned Phase 2/3 clinical trial of suvodirsen, DYSTANCE 51, was the first study ever selected for the FDA pilot program for complex innovative trial designs (CID).

    About Wave Life Sciences

    Wave Life Sciences (NASDAQ: WVE) is a clinical-stage genetic medicines company committed to delivering life-changing treatments for people battling devastating diseases. Wave aspires to develop best-in-class medicines across multiple therapeutic modalities using PRISM, the company’s proprietary discovery and drug development platform that enables the precise design, optimization and production of stereopure oligonucleotides. Driven by a resolute sense of urgency, the Wave team is targeting a broad range of genetically defined diseases so that patients and families may realize a brighter future. To find out more, please visit www.wavelifesciences.com and follow Wave on Twitter @WaveLifeSci.

    Forward-Looking Statements

    This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, the planned presentation today of the final results from the Phase 1 clinical trial of suvodirsen in DMD, the expected timing of initiation of the Phase 2/3 clinical trial for suvodirsen in DMD, the plans to report interim efficacy data from the ongoing open-label extension study with patients from the Phase 1 clinical trial of suvodirsen in DMD, the belief that the safety and tolerability data from the Phase 1 clinical trial supports initiation of a Phase 2/3 clinical trial, Wave’s intention to use the results of the Phase 2/3 trial to seek regulatory approvals, Wave’s plans and expectations regarding the design of the Phase 2/3 clinical trial, and Wave’s expectations regarding the selection of the Phase 2/3 trial for the FDA pilot program for complex innovative trial design. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release. These risks and uncertainties include but are not limited to the following: Wave’s current and planned clinical trials, other studies for suvodirsen, and Wave’s other product candidates may not be successful or may take longer and be more costly than anticipated; product candidates that appeared promising in earlier research and clinical trials may not demonstrate safety and/or efficacy in later-stage or larger-scale clinical trials; and the other risk factors discussed under the heading “Risk Factors” contained in Wave’s Annual Report on Form 10-K for the year ended December 31, 2018 filed with the Securities and Exchange Commission (SEC), as well as in other filings Wave makes with the SEC from time to time. All statements contained in this press release are made only as of the date of this press release, and Wave undertakes no obligation to update the information contained in this press release to reflect subsequently occurring events or circumstances.

    Investor Contact:Kate Rausch617-949-4827krausch@wavelifesci.com

    Media and Patient Contact:José Juves617-949-4708jjuves@wavelifesci.com


    Health calendar — April 9 | killexams.com real questions and Pass4sure dumps

    Alcoholics Anonymous meetings — No dues or fees. For times and locations, call 301-662-0544.

    Altateen — 7:30 to 8:30 p.m. Tuesdays, Grace Episcopal Church, 5740 Green Valley Road, New Market. Meets weekly, support for young relatives of alcoholics, ages 10 to 19; part of Alanon. www.alateenmddc.com.

    Alzheimer’s Support Groups:

    Cancer Support Group — 10 to 11:30 a.m. every Friday, Monocacy Valley Church, 9861 Old National Pike, Ijamsville. For those surviving or battling this disease, an opportunity for fellowship with others on a regular basis. Family members welcome. Details at 301-865-9100 or www.mvcnow.org.

    Celebrate Recovery — 7 p.m. Thursdays at Grace Community Church, 5102 Old National Pike, Frederick. Participate in group fellowship where love and hope combine with God’s purpose to mend their lives. Free. 301-473-4337.

    Celebrate Recovery — 7 p.m. Mondays, Church of the Redeemer-Frederick Campus, 5606 Buckeystown Pike, Frederick. 240-238-1507

    Celebrate Recovery — 7 p.m. Mondays, Faith Baptist Church, 2212 Jefferson Pike, Knoxville. Fellowship and celebrate God’s healing power in life through the Eight Recovery Principles found in the Beatitudes and Christ-centered 12 steps. 301-834-7755, ext. 104.

    Daytime Grief Support Group — 2 to 3:30 p.m. Tuesdays, Hospice of Frederick County, 516 Trail Ave., Suite A, Frederick. On-going support for individuals who have experienced the death of a loved one. Participants can share stories and express their grief. Free. dwatterson@fmh.org; 240-566-3030.

    Evening Grief Support Group — 5 to 6:30 p.m. second and fourth Monday of the month, Hospice of Frederick County, 516 Trail Ave., Suite A, Frederick. Ongoing support for individuals who have experienced the death of a loved one. Free. 240-566-3030.

    Evening GriefShare Support Group — 7 to 9 p.m. Wednesdays, St. Ignatius of Loyola, 4103 Prices Distillery Road, Ijamsville. For anyone suffering from a recent or past loss of a loved one. 301-695-8845.

    Food Addicts in Recovery Anonymous — 9 to 10:30 a.m. Saturdays, South End Baptist Church, 506 Carrollton Drive, Frederick. Many people are finding recovery in FA from obesity, undereating, bulimia, and obsession with food. There are no dues or fees. Meets weekly. Angela, 301-758-3614, or Moya, 641-680-3354. www.foodaddicts.org.

    Friends in Frederick Parkinson’s Disease Support Group — 1 to 3 p.m. the third Wednesday of the month, Mount Pleasant Ruritan Club, 8101 Crum Road, Walkersville. Typically a guest speaker and informal discussion time. For information, contact John at 301-703-1194 or www.fifpdsg.org.

    Frederick Area Ostomy Support Group — 2 to 4 p.m. the second Sunday of the month, Frederick Memorial Hospital Volunteer Conference Room, use Entrance 3, 400 W. Seventh St., Frederick. Join the group if you need support or want to offer support to new ostimates. 301-663-1203.

    Gamblers Anonymous — 10:30 a.m. to noon Tuesdays at Mount Pleasant United Methodist Church, 9550 Liberty Road, Frederick. www.gamblersanonymous.org.

    NAMI Family and Friends Support Groups — 6:30 to 8 p.m. third Wednesday of the month, All Saints’ Episcopal Church, 106 W. Church St., Frederick, 240-379-6286. Relaxed group meets to support family and friends of those with mental illness. Ages 18 and older. Membership in NAMI is not required. http://newsite.namifcmd.org.

    NAMI Connection Recovery Support Group — 7 to 8:30 p.m. Tuesdays, Evangelical Lutheran Church Rupp House, 35 E. Church St., Frederick. Support for adults living with mental illness. Casual, relaxed group. Ages 18 and older. 240-379-6186 or www.namifrederick.org.

    Overeaters Anonymous — 7 p.m. Thursdays, 10:30 a.m. Saturdays, Trinity United Methodist Church, 703 W. Patrick St., Room 103, Frederick. Not a diet club, but a fellowship of people recovering from compulsive over and/or under-eating. www.northernblueridgeoa.org.

    Peer Support for Amputees — 6 to 7 p.m. April 16, C. Burr Artz Library, 110 E. Patrick St., Frederick. Faith-based group open to anyone who would like to attend. The mission of the support group is to provide a safe place for amputees to come together and share their story with others who can relate to the challenges. Having peers who are there to listen, understand, and encourage you as you navigate your new normal is crucial. Free. 443-432-5744 or psa2018frederickmd@gmail.com.

    Refuge Recovery: A Buddhist Path to Recovering from Addiction — 7:30 to 8:30 p.m. Mondays, and 6:30 to 7:30 p.m. Thursdays at 309 E. Patrick St., Frederick. Non-theistic, Buddhist-inspired approach to recovery from addictions of all kinds. Peer-led meetings meet weekly. Free, but donations welcome. mlw0720@gmail.com or www.refugerecovery.org.

    Steps to Eternity Co-Dependents Anonymous (CoDA) Meeting — 7 to 8 p.m. Tuesdays, Christ Reformed UCC, 12 S. Church St., Middletown. 12-step fellowship of men and women whose common purpose is to develop healthy relationships. Ages 18 and older. 240-626-5933.

    Survivors of Suicide Support Group — Mental Health Association of Frederick County offers a support group for adults who have lost a loved one to suicide. Led by a trained facilitator. For meeting time and location, call 301-663-0011.

    The Ranch Family Support Group — 4:30 to 5:30 p.m. Sundays, The Ranch, 7902 Fingerboard Road, Building F, Frederick. For individuals with family members that have loved ones involved in addiction. Free 301-874-4701 or www.ranchmd.org.

    Transitions Support Group — 2 to 3:30 p.m. second Tuesday of the month, Hospice of Frederick County, 517 Trail Ave., Frederick. For those one year out or more from death of a loved one. Second group meets 5 to 6:30 p.m. 240-566-3030 or www.hospiceoffrederick.org.

    Medical Weight Loss — A Path to a Healthier You Starts Here! — 9:30 a.m. Friday, FMH Crestwood, 7211 Bank Court, Frederick. The FMH Center for Diabetes and Nutrition Services’ qualified healthcare team and maintenance program set us apart from other area weight loss programs. For adults ready to make the lifestyle changes needed to lose weight. Free orientation to learn about the three weight-loss options. RSVP required. http://tinyurl.com/y3y7cbsj or 240-215-1472.

    Yoga for Knee Strength and Flexibility — 3 to 5 p.m. Saturday, Yogamour, 1 Worman’s Mill Court, Frederick. Are your knees giving you trouble? Are your knees clicking and popping? Is kneeling or moving your knees in certain directions completely out of the question? This workshop will lead you in movements to find more flexibility and strength in your knees so that you can continue to move and walk well as you age. $30. Register at www.yogamour.org.

    Lungs for Life Seminar — 5:30 to 8 p.m. April 17, James M Stockman Cancer Institute, 1562 Opossumtown Pike, Frederick. Program begins at 6 p.m. Hear from local medical experts on lung cancer screening and thoracic surgical interventions; smoking cessation; stigma of lung cancer and coping; target and immunotherapy for lung cancer. Refreshments. Call 240-566-4370 by April 10 to request an interpreter. http://tinyurl.com/yxnghju8.

    Parkinson’s Disease Community Seminar — 9 a.m. to 4 p.m. April 19, Otterbein UMC, 108 E. Franklin St., Hagerstown. Hosted by the Four State Alliance for Parkinson’s Support, spear-headed by the Hagerstown Parkinson’s Support Group and the Friends in Frederick Parkinson’s Disease Support Group. The goal is to expose persons associated with Parkinson’s disease in the 4-state area to some of the top experts in the field and to many of the services available to them. Space is limited, early registration is recommended. $10. 240-625-2722 or www.fareshare.net/Parkinsons.

    Respect the Joint: Arthritis and You — 11:30 a.m. to 1 p.m. April 24, Ceresville Mansion, 8529 Liberty Road, Frederick. Presented by FMH Select, join Dr. Mihir Jani and Dr. Jason Matthews in the exploration of current treatment options for knee and hip osteoarthritis. Dinner menu features a choice of brown sugar and dark rum glazed chicken breast with an apple and gouda stuffing or ricotta-stuffed pasta shells topped with pesto cream sauce and fresh parmesan. 240-379-6031.

    Art of Thinking Series Session 3: Mental Fitness Across the Lifespan — 7 to 8:30 p.m. Tuesday, YMCA Community Room, 1000 N. Market St., Frederick. Topics covered will include everyday brain-fitness recipes, a demonstration “From Yoga to Physiology to Mindfulness,” anxiety and its effect on brain centers, and the Art of Thinking group exercises. Free. 301-471-0148.

    Life Line Screening — By appointment only April 16, American Legion Post 11, 1450 Taney Ave., Frederick. Screenings can check for plaque buildup in arteries, cholesterol, diabetes risk, bone density, kidney and thyroid function, and more. Packages start at $149. Pre-registration required. 877-237-1287 or www.lifescreening.com.

    Energy Healing — 9:30 to 10 a.m. Sundays, Unity in Frederick — A Spiritual Community, 5112 Pegasus Court, Suite E, Frederick. Offered by the healing practitioners of Unity’s healing ministry. Followed by celebration service, coffee and fellowship. Free. 301-846-0868 or www.unityfrederick.org.

    Call 800-733-2767 or go to redcrossblood.org/make-donation to schedule appointments or to verify blood drive will be taking place. Call the Frederick American Red Cross Blood Donation Center, 141 Thomas Johnson Drive, to schedule appointments for blood, double red cells and apheresis donations. Schedule subject to change.

    April 11 — 10 a.m. to 3:30 p.m., Frederick Community College, 7932 Opossumtown Pike, Frederick

    April 11 — 2:30 to 8 p.m., Emmitsburg Vigilant Hose Activity Building, 17701 Creamery Road, Emmitsburg

    April 16 — 12:30 to 6 p.m., Whitaker Campus Center Commons, 401 Rosemont Ave., Frederick

    April 16 — 9:30 a.m. to 2:30 p.m., Mount Saint Mary’s University, 16300 Old Emmitsburg Road, Emmitsburg

    April 16 — 1 to 6 p.m., Damascus Public Library, 9701 Main St., Damascus

    To have your nonprofit health and fitness events considered for the Health & Fitness calendar, it must be submitted to the online calendar at www.fredericknewspost.com/calendar. Items for publication must be received at least 10 days prior to publication.



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