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000-643 UCM Essentials

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000-643 exam Dumps Source : UCM Essentials

Test Code : 000-643
Test Name : UCM Essentials
Vendor Name : IBM
: 46 Real Questions

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IBM UCM Essentials

Oracle regularly occurring content management lives up to the identify | Real Questions and Pass4sure dumps

it be now not always useful or cost-effective for large organizations to consolidate their disparate methods that keep unstructured content corresponding to documents, internet cloth, and digital media. Yet holding these siloed applications introduces different prices and hazards, together with lack of protection and statistics administration. ECM (commercial enterprise content material management) techniques handle these shortcomings while leaving your latest file servers and different repositories in location. despite the fact ECMs usually require yet one other database, clients proceed gaining access to their latest computer info and procedures, while the content material manager gives centralized storage, indexing, versioning, workflow, retention, and other features.

[ See also: InfoWorld Technology of the Year Awards Data Management winners ]

probably the most greater ECM items turned into Stellent regular content material administration, which Oracle got when procuring Stellent in late 2006. As you might predict, the renamed and up-to-date Oracle UCM (familiar content material management) unlock 10g R3 is now more suitable built-in with Oracle's different products. as an instance, UCM has an out-of-the-field issuer for Oracle Database (making it less demanding to configure the database and to perform backups). Plus, as a part of Oracle Fusion Middleware, UCM is "hot pluggable" into latest Oracle servers and can take potential of the enterprise's grid infrastructure, corresponding to application clusters.

UCM edition 10g R3 is also extra open than outdated incarnations. An protected internet half lets users work with content from within Microsoft SharePoint. additionally, there is new Outlook e mail integration, smoother operation with windows Explorer, and an automatic WSDL generator that makes it more straightforward to integrate UCM with other functions that devour web functions.

thumb93163.pngclick on for larger view.

content material in, content out

i've been hammering away at Oracle UCM -- which contains Oracle content material Server, document management modules, and the time-honored content administration pieces (internet content management, digital belongings management, and statistics management) -- for just a few weeks on a home windows Server 2003 machine. Oracle Database 10g XE become my database engine. My usual affect is that superior usability, integration, and filing (greater than 400 file formats are automatically transformed the usage of web functions) make UCM a superb providing.

Contributing content material to the repository required no additional steps as I dragged and dropped Microsoft observe and other document varieties from my laptop to a UCM folder that regarded inside windows Explorer. Oracle immediately applied metadata, whereas adding alternatives to pop-up menus for document administration capabilities reminiscent of try. in a similar way, Oracle-managed folders within Microsoft Outlook let me submit e-mails and attachments as records; I then managed this content material directly from Outlook (similar to looking and taking it offline for modifying).

once I positioned excessive-resolution photographs into a managed folder, UCM automatically created variations at distinctive sizes and resolutions, comparable to ones applicable for the net.

The web interface to UCM, a personalized portal for every consumer, now comprises a leaner appear and context-specific menus. Search enhancements, however, make up the majority of alterations. the new question builder helped me create advanced queries devoid of writing any advanced Boolean good judgment. additionally, it was easy to slender searches the use of metadata that turned into associated with files. UCM takes this a step additional by using metadata depending on situations or a person's role. as an example, which you can search for under objects containing a product name it is to your workflow.

One widespread search function that UCM implements is Tag Clouds: Readers can browse keywords and notice which might be the most time-honored. Optionally, which you could cost content to raise or decrease its place in search consequences. additional, UCM generates an RSS feed for custom searches; these consequences are then saved in a personal search enviornment of the portal.

It goes devoid of asserting in these internet 2.0 instances that UCM doesn't limit RSS to Saved Queries. I effectively set up feeds to reveal my Workflow Inbox and Checked Out items. yet another vital characteristic let me create feeds containing utilization analytics; this may, as an instance, enhance a support desk utility where the RSS feed suggests the most common competencies base articles. I also liked the wealthy formatting of feeds, which may also automatically contain thumbnail photos, text abstracts, and selected metadata.

thumb93161.pngclick on for larger view.

I encountered content Conversion Server, which is now a provider-oriented structure, all through testing. for example, when looking search effects, UCM referred to as this provider to transform Microsoft observe files into PDF and reveal them in a preview pane.

the new Oracle net constituents for SharePoint worked with none catches. After logging into my verify SharePoint server operating the Oracle UCM web part, I uploaded documents to the UCM repository and additionally used UCM search. This helpful integration allows for users to save data in UCM, collaborate and manage these belongings the usage of SharePoint points, yet reuse this equal content material in net sites or the enterprise intranet via Oracle.

easy internet CM

Managing net sites is easy for a number of reasons. First, for the reason that they are being served from content Server, which you can take talents of latest personalization and security. second, a Contributor mode makes including and modifying content a breeze.

here's a standard state of affairs: After logging into the content Server, I opened the internet sites enviornment and displayed my corporate website. in accordance with my login, UCM understood what permissions I had to add or change content material. the use of the new web page Studio supervisor, an AJAX-primarily based (Asynchronous JavaScript and XML) device, I brought sections to the site and populated content with a Microsoft note doc already in the repository. UCM automatically transformed the doc and applied the appropriate seem to be and suppose in response to an internet trend sheet (.css).

thumb93162.pngclick for better view.

Workflows, each fundamental and complicated, are developed with an analogous visible technique. For my internet web page examine, I routed paged edits through a prison department; requests looked in an legal professional's Workflow Inbox in content Server, and the person also received electronic mail notifications.

Oracle customary content administration is a deep product, and i've simplest touched on the leading new points. when I step lower back and determine the average architecture, it too makes lots of experience for big organizations. as an instance, UCM information management and rights management can also be applied to your other systems, akin to file servers and e-mail archives. In itself, this could simplify suggestions administration all the way through an organization and cut back fees.

youngsters implementing a full UCM equipment would be a big engaging in, Oracle has became commonplace content material administration into a much better, greater open product it really is definitely competitive with the different main ECM providers: EMC Documentum, IBM FileNet, Interwoven, and OpenText. Of the open source CMS items, Alfresco comes closest to Oracle UCM, though I trust UCM is superior in most areas, notably usability and protection.

InfoWorld Scorecard

Ease of use (25.0%)

facets (25.0%)

value (10.0%)

protection (15.0%)

Scalability (15.0%)

administration (10.0%)

normal rating (a hundred%)

Oracle frequent content material administration 10g R3 9.0 eight.0 eight.0 9.0 9.0 9.0 8.7

How 6 enterprise content management techniques help Collaboration | Real Questions and Pass4sure dumps

You guys went nuts over their listing of social systems for enterprise collaboration, so they idea we'd switch things round and focus on a handful of the important avid gamers within the ECM online game which are helping group work and social solutions. 


IBM's (news, web site)  social utility, Lotus Connections, was most currently mentioned at Lotusphere 2010, the place edition 2.5  flaunted here new and built-in facets: 

Communities: The neighborhood feature has been more desirable swanky new dialogue forums that reveal the variety of replies for each and every subject, and neighborhood homeowners can customize the appear of their community and circulate widgets round on their domestic page.Wikis: New constructed-in revision history enables clients to check out old types.files: File sharing equals much less inbox overload.cellular access: mobile browser assist for Lotus Connections Profiles (Apple iPhones or Nokia s60 gadgets).Federated Updates: A new Updates tab shows critical news gadgets from throughout a consumer's social community. Microblogging: Ah, the infamous fame update, now featured in Lotus Connections Profiles. A profile "board" additionally permits clients to post messages to different profiles. stronger Search: Search all connections functions, and filter by tags, person, or time range.

Quickr, large Blue's team collaboration software that works with ECM, become additionally discussed on the conference after Alfresco announced their integration of it. Quickr features consist of:

  • content material libraries: right now prepare and share content material
  • crew areas: create on-line places for projects or teams
  • Connectors: work where you are with out switching functions
  • content repositories: safety-prosperous areas on your Lotus Quickr server where Lotus Quickr libraries and team content material are kept
  • Templates: use pre-built crew places to get began quickly
  • RSS/ATOM feeds: dwell up to date and within the comprehend 
  • Alfresco

    speaking of Alfresco (information, web page), Alfresco Share is built on the company's doc repository, offering out-of-the-box content administration with collaboration elements like:

    document Library: here, users can view content material in spite of its originating software or product version (i.e. Microsoft workplace 2007). 

    exercise Feeds: here is one more universal one. With recreation feeds, Alfreso Share clients can track what is new or altering in a challenge web site, on content that's added or edited, comments, and on new crew contributors and critical calendar dates.

    Create digital teams: search for people and experts just as you possibly can search for content material.

    SharePoint Protocol aid: Alfresco presents Microsoft workplace SharePoint Protocol support, enabling clients to reduce can charge without a additional client installing required. 

    Open text

    previously called Vignette community applications, Open text (information, website) Social Communities is a social business answer with a unified framework that facets:

    Blogs: You know the drill with this one-- yay for information conversations.Wikis: Open textual content's Wikis are modular and configurable vehicles for aggregating neighborhood skills. boards: As crew Open textual content says, "boards frequently identify influential leaders and field rely consultants who may also be of improvement to your organization each within the discussion board context and in other places."Moderation: This one is extra-cool because it allows users to offer protection to the quality of content material with dashboards that feature approve or reject UGC options.Social microsites: With social microsites, clients can create compelling social microsites. Adaptable templates give you the flexibility to mix the imperative features to satisfy your certain dreams, corresponding to launching a brand, product or crusade. besides typical web 2.0 points, the social microsite capabilities consist of:

  • hobbies/calendar administration
  • thought management
  • Social networking
  • Video, image, and podcast sharing
  • probably the most contemporary release of Open textual content ECM Suite 2010 claims comprehensive integration (integrated internally or on extranet) and cellular options are on the way. 

    SharePoint 2010

    The a great deal referred to SharePoint 2010 works towards social goals via assisting 

  • specified user profiles 
  • modern tools for sharing and collaboration including blogs, wikis, RSS feeds and pastime streams
  • special interest groups (Communities) to share skills or work on tasks 
  • Commenting and discussions round content material gadgets, and social tagging/bookmarking of content material
  • Separate very own areas or dashboards called MySites where users can hold music of content material, , initiatives and more:
  • Memberships.jpg

    SharePoint 2010 — rich person Profiles


    part of the collaboration buzz for Oracle (information, site) is around Beehive, the enterprise's built-in set of modular and scalable collaboration services developed on a single platform. The three areas of Beehive's center of attention are

    commercial enterprise Messaging (comprises integration with MS Outlook & cellular support)
  • personal electronic mail, Calendar, tackle ebook & task administration
  • entry to crew Workspaces together with team Calendar, Inbox, and files
  • internet and Audio conference Scheduling
  • Contextual Search
  • Artifact Tagging
  • crew Collaboration
  • Templates for growing Workspaces
  • document Library (version monitoring; Workflow manage guide; far off content material Sharing with Oracle UCM)
  • group Wiki (wealthy textual content Editor; support for Plug-ins including HTML Widgets)
  • crew Calendar
  • team task administration
  • dialogue boards
  • Microblogs
  • Contextual Search with Search results Filtering
  • Shared Tags and Tag Clouds
  • RSS Feeds
  • actual-Time Collaboration
  • Create and Host immediate or Scheduled net and Audio Conferences
  • internet Conferencing
  • computer and software Sharing
  • far off control and Shared manage
  • textual content Chat
  • assembly Recording (together with audio, group chat, and displays)
  • time table conferences by means of Microsoft Outlook, Beehive Webmail or any standards-based CalDAV customer
  • it be a great deal to take it, but which you can try the complete load of Beehive here. meanwhile, Oracle additionally offers the WebCenter suite, an open portal platform that integrates enterprise 2.0 capabilities into enterprise processes and custom and packaged commercial enterprise purposes. 

    The platform bundles collectively ECM, business search, business procedure management, and presence capabilities. As a “scorching-pluggable” part of Oracle Fusion Middleware, it beefs up the value of existing strategic investments via integrations with offerings like Oracle Database, Oracle identity management, Oracle enterprise Intelligence and Oracle applications.

    EMC Documentum

    EMC's (news, web page) CenterStage is a B2B collaboration answer constructed for each the cellular competencies employee and workplace worker. a shopper to EMC's commercial enterprise content management device, Documentum, CenterStage takes advantage of frequent business 2.0 equipment and operates with three core issues in intellect: group productivity, company method Automation and tips Discovery. 

    There are two types: CenterStage necessities offers primary content material capabilities and team workspaces, and CenterStage professional adds very own workspaces, wikis, blogs and superior search and discovery equipment (check out the details here). 

    here's simply a brief and dirty evaluate of a handful of alternate options, but it surely's no longer a bad delivery if you're seeking to enter the market. As at all times, tips for extra options are welcome in the feedback area. 

    Mortality from heart Failure reduce in Half in Weight-Loss surgical procedure… | Real Questions and Pass4sure dumps

    Mortality from heart Failure reduce in Half in Weight-Loss surgery patients

    NASHVILLE, Tenn. (PRWEB) November 13, 2018

    New Cleveland hospital look at suggests Bariatric surgery may additionally Have defensive effect After coronary heart Failure

    sufferers who have in the past undergone weight-loss or bariatric surgery, and later endure unrelated coronary heart failure, cut their possibility of death in half in comparison to people who did not have surgery, based on a brand new look at from Cleveland medical institution researchers who presented their findings* today at ObesityWeek 2018, the largest international scientific convention focused on the prevention and medicine of obesity hosted by way of the American Society for Metabolic and Bariatric surgical procedure (ASMBS) and The obesity Society (TOS).

    based on the centers of ailment manage and Prevention (CDC), 5.7 million adults in the U.S. have coronary heart failure,[1] a persistent and innovative circumstance wherein the coronary heart is unable to pump sufficient blood to satisfy the body’s wants for blood and oxygen.[2] About half of these clinically determined with the situation die inside five years.[3]

    Researchers reviewed information on 33,720 patients who have been admitted to the clinic for coronary heart failure between 2007 and 2014 and in comparison outcomes between these with and with out a history of prior bariatric surgery. The surgery group included 2,810 sufferers and two handle agencies of 14,050 patients each and every, one confined to sufferers with a physique mass index (BMI) of 35 or more and the other such as patients of all BMIs. statistics became bought from the country wide Inpatient sample (NIS), the greatest all-payer inpatient healthcare database. On common, patients had been sixty one-years-ancient and approximately 60 % were ladies.

    In-hospital mortality fees after coronary heart failure had been 50 p.c much less within the bariatric surgery group than both of the control organizations (0.96% versus 1.86%), and the surgical sufferers spent about one much less day within the hospital.

    “A 50 % reduction in in-sanatorium all-trigger mortality is an exceptional discovering. There seems to be a major protecting and survival improvement after bariatric surgery however sufferers later enhance heart failure,” pointed out Ali Aminian, MD, lead look at creator and affiliate professor of surgery at the Cleveland health center, Ohio. “The mechanism by which bariatric surgical procedure impacts coronary heart failure continues to be below investigation, but this analyze means that some cardiac advancements may additionally happen unbiased of weight loss.”

    according to the American coronary heart association, weight problems raises the chance of coronary heart ailment. The community cites research from the Framingham coronary heart study that found that americans with weight problems “had a fantastic 104% increase within the risk of establishing heart failure in comparison to non-overweight people.”[4] coronary heart failure bills for greater than 1 million hospitalizations in the U.S. annually and is the main reason behind hospitalization for adults over the age of 65.[5]

    “while development in cardiovascular chance elements after bariatric surgery is smartly documented, this analyze suggests should a cardiac event like heart failure happen, the possibilities of survival are tons greater for bariatric surgical procedure patients than sufferers with severe weight problems who do not bear an operation,” referred to Samer Mattar, MD, president, ASMBS and clinical director at Swedish weight reduction services in Seattle Washington, who turned into now not concerned within the look at.

    The CDC experiences 93.3 million or 39.eight percent of adults in the U.S. had weight problems in 2015-2016.[6] The ASMBS estimates about 24 million have extreme weight problems, which for adults skill a BMI of 35 or greater with an obesity-linked circumstance like diabetes or a BMI of 40 or greater. In 2017, 228,000 bariatric approaches had been performed in the U.S., which is set 1 percent of the population eligible for surgery in keeping with BMI.

    Metabolic/bariatric surgical procedure has been proven to be probably the most advantageous and lengthy-lasting medicine for severe obesity and many connected conditions and consequences in gigantic weight reduction.[7] The agency for Healthcare research and satisfactory (AHRQ) stated giant improvements within the defense of metabolic/bariatric surgical procedure due in gigantic half to improved laparoscopic recommendations.[8] The risk of dying is set 0.1 %[9] and the common chance of principal problems is ready 4 p.c.[10] according to a examine from the Cleveland health facility’s Bariatric and Metabolic Institute, laparoscopic bariatric surgery has complication and mortality prices corresponding to one of the most secure and most commonly carried out surgical procedures in the U.S., including gallbladder surgery, appendectomy and knee replacement.[11]

    concerning the ASMBSThe ASMBS is the biggest firm for bariatric surgeons in the nation. it is a non-profit company that works to boost the artwork and science of bariatric surgical procedure and is dedicated to teaching clinical professionals and the lay public about bariatric surgery as an alternative for the medication of extreme obesity, as well because the associated risks and advantages. It encourages its participants to investigate and discover new advances in bariatric surgical procedure, while maintaining a gentle trade of experiences and ideas that may also lead to greater surgical effects for patients with severe obesity. For extra advice, visit


    *Bariatric surgery Decreases Mortality of Congestive heart Failure: A Nationwide analyze (A105)Essa M. Aleassa, MD[1]; Zhamak Khorgami, MD[2]; Chao Tu, MS[1]; Philip R. Schauer, MD[1]; Stacy Brethauer, MD[1]; Ali Aminian, MD, FACS, FASMBS[1] — all from Cleveland clinic; Cleveland, OH[1]; Tulsa, adequate[2]


    [1][2][3][4] https://www.coronary heart-public/@wcm/@adv/documents/downloadable/ucm_305059.pdf[5] coronary heart disease and stroke facts—2017 replace: a record from the American coronary heart affiliation. Circulation. Chapter 21: Cardiomyopathy and coronary heart Failure. Pages e523-e538 Accessed October 2018 from[6] problems/information/grownup.html[7] Weiner, R. A., et al. (2010). indications and concepts of metabolic surgery. U.S. national Library of medicine. 81(4) pp.379-394. Accessed October 2018 from[8] Encinosa, W. E., et al. (2009). fresh improvements in bariatric surgical procedure effects. medical Care. forty seven(5) pp. 531-535. Accessed October 2018 from[9] agency for Healthcare analysis and great (AHRQ). (2007). Statistical short #23. Bariatric surgical procedure Utilization and results in 1998 and 2004. Accessed October 2018 from[10] Flum, D. R., et al. (2009). Perioperative defense in the longitudinal evaluation of bariatric surgical procedure. New England Journal of drugs. 361 pp.445-454. Accessed October 2018 from material/full/361/5/445[11] Gastric pass is as safe as frequently carried out surgeries. fitness essentials. Cleveland hospital. Nov. 6, 2014. Accessed October 2018 from procedures/ Contact writer

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    St. Peter's Health Partners to improve care for victims of sexual assault | real questions and Pass4sure dumps

    ALBANY, N.Y. — St. Peter’s Health Partners (SPHP) recently announced a new telemedicine program in partnership with United Concierge Medicine (UCM), made possible through a collaboration with New York State, to improve care for victims of sexual assault.

    The program, TeleSAFE, allows for more timely and comprehensive care for victims who seek medical assistance at rural or underserved hospitals that lack a provider with Sexual Assault Forensic Examiner (SAFE) certification, according to officials.

    With TeleSAFE, officials noted that the emergency department (ED) providers at these hospitals will now have the ability to contact UCM’s Virtual ER SAFE-certified providers at any time through a secure video connection. These SAFE-certified providers will then guide the ED staff through the process of medical and forensic exams, according to a news release.

    The TeleSAFE pilot launched recently and allows 46 hospitals in the Capital Region and Central New York without SAFE certification to access SAFE-certified providers 24 hours a day, seven days a week. Hospitals eligible for the program may participate and offer this service for no cost.

    The pilot is funded by $2.85 million in federal funding administered by the New York State Office of Victim Services (OVS), in addition to a $300,000 grant from the New York State Department of Health (DOH). The grants are administered by the St. Peter’s Hospital Foundation at SPHP, which is managing the program in partnership with Troy-based UCM. TeleSAFE utilizes telemedicine technology developed by UCM.

    “At St. Peter’s Health Partners, they work every day to be a compassionate and transforming healing presence in the communities they serve,” SPHP Chief Clinical Officer Dr. Steven Hanks said in the release.

    “The TeleSAFE program is a platform that allows SAFE-certified providers to help their colleagues at other hospitals provide timely, compassionate, respectful, and patient-centered care to those who need it most. They are proud to partner with the New York State Office of Victim Services, New York State Department of Health, and United Concierge Medicine on this new program,” Hanks added.

    An increase in funding through the federal Victims of Crime Act has allowed the state Office of Victim Services to fund this initiative and other innovative programs, all designed to improve services and reach individuals of any age who are victims of crime, wherever they live. An exam may also include the collection and preservation of evidence, which can assist law enforcement if an individual decides to report the crime. Reporting is not mandatory, however, and should never prevent someone from seeking medical care, officials noted.

    “We are thrilled to provide the funding for this pilot because access to medical care in the aftermath of sexual assault is critical to an individual’s physical and mental well-being,” Office of Victim Services Director Elizabeth Cronin said in the release.

    “Seeing a medical provider immediately can address those needs, connect individuals with victim services, and may allow evidence to be collected and preserved. Comprehensive care and support can make all the difference in how an individual heals in the aftermath of a traumatic event,” Cronin added.

    In addition, officials noted that legislation signed last year by New York Gov. Andrew M. Cuomo requires hospitals to retain sexual offense evidence collection kits for 20 years, instead of 30 days. This measure gives survivors the time and space to heal before deciding to report the crime.

    “It is critical that hospitals across New York State deliver timely and comprehensive care to individuals who have been victims of sexual assault,” New York State Health Commissioner Dr. Howard Zucker stated in the release.

    “By helping to fund the TeleSAFE program, they are making a difference in ensuring the health care system supports victims of sexual assault and supports their rights to access essential medical care,” Zucker added.

    “Access to SAFE providers is a public health crisis disproportionally impacting small and rural hospitals,” United Concierge Medicine CEO Keith Algozzine noted in the release.

    “No one should be denied timely care because the hospital has no SAFE-certified provider available. That’s why UCM is so excited to offer this unique and innovative technology to victims of sexual assault. They hope all hospitals who do not have 24/7/365 SAFE providers available will partner with us to ensure victims of sexual assault receive the care they need,” Algozzine added.

    Currently, there are 44 SAFE-certified hospitals in New York, according to the DOH. These include SPHP affiliates St. Peter's Hospital in Albany and Samaritan Hospital in Troy. A SAFE-certified facility meets strict criteria for standards of care and provides coverage for victims of sexual assault 24 hours a day, seven days a week. Of those 44 SAFE-certified hospitals, 27 are located in or around the New York City metropolitan area, and the remaining 17 are upstate, according to the release.

    The new TeleSAFE pilot program will allow 46 hospitals in the Capital Region and Central New York without SAFE certification to have virtual access to SAFE-certified providers at any time. Eighteen of these 46 hospitals are designated by the Centers for Medicare and Medicaid Services (CMS) as critical access hospitals. This designation means they are more than 35 miles away from another hospital and meet other additional criteria.

    Officials said the TeleSAFE program provides a clear process for hospitals without SAFE certification. When a sexual assault survivor presents to a hospital’s ED using the TeleSAFE program, a patient advocate is contacted to help support the patient through the exam. After a patient has consented to use the service, the ED provider contacts UCM’s Virtual ER to coordinate the care with the SAFE-certified provider.

    Officials said that the TeleSAFE provider can walk any ED provider through this exam, which usually lasts for several hours, using telemedicine technology. They are able to assist with taking a history of the assault, collecting photographic evidence, as well as collecting the best forensic evidence possible. Following the exam, they will also assist the hospital-based provider with completing documentation and ordering any additional testing or medication.

    With this process, the TeleSAFE program allows rural and underserved hospitals to perform SAFE exams in compliance with DOH regulations, in a timely manner, and without the need to transfer the patient to another hospital, according to the release.

    Officials noted that TeleSAFE services are also being offered to SAFE-certified centers in the pilot area. For these hospitals, the expert TeleSAFE providers are able to provide expert consultation to examiners with questions during exams, as well as serving as a preceptor for newly trained examiners, which is a requirement of the DOH training process.

    If you’d like to learn more about TeleSAFE you can visit Hospitals seeking to join the TeleSAFE program should contact UCM at or 833-835-7233.

    Study opens new avenue for treating ulcerative colitis or Crohn's disease | real questions and Pass4sure dumps

    An international study led by the Complutense University of Madrid (UCM) and the National Centre for Cardiovascular Research (CNIC) has found that Lactobacillus bacteria present in the intestinal microbiota interact with immune system cells to strengthen the intestinal barrier.

    Conducted on mice and published in Immunity, the study opens a new avenue for the treatment of diseases such as ulcerative colitis or Crohn's disease, in which the intestinal barrier becomes so weakened that bacteria can migrate to other organs, causing inflammatory processes.

    Until now, only a few descriptions have existed of specific commensals in mouse microbiota that stimulate the immune system and regulate the lymphocyte population, which helps ensure that bacteria remain in the niche where they are beneficial.

    "Our research shows that there are molecular patterns present in or secreted by commensal intestinal bacteria which are recognised by a receptor in the immune system cell called Mincle", reported El Salvador Iborra, a researcher in the Department of Immunology, Ophthalmology and ENT at the UCM.

    This interaction between Mincle and beneficial Lactobacillus bacteria occurs in regions of the small intestine called Peyer's patches and promotes a beneficial response in the host.

    A reduction in lymphocytes leads to a weakened barrier

    To carry out the study, the researchers used Mincle-deficient mice, or mice deficient in one of the proteins involved in intracellular signalling of this receptor, called Syk.

    The researchers found that this deficiency led to a failure to produce the instructions necessary to generate the intestinal lymphocytes essential for regulating the intestinal immune barrier function.

    "We found that as a result of this reduction in the lymphocyte population, intestinal barrier function deteriorated, leading to an increase in the number of bacteria capable of migrating from the intestine and reaching the liver, generating hepatic inflammation and metabolic changes", Iborra explained.

    The results of this study open a new avenue for treating disease, such as "the administration of beneficial probiotic microorganisms capable of interacting with this receptor, or prebiotics capable of promoting the growth of these intestinal bacteria", noted the UCM researcher. Iborra also added another possibility: treatment with synthetic compounds capable of binding to Mincle and triggering the beneficial response mediated by this receptor.

    In addition to inflammatory bowel diseases, stress, poor diet or overuse of drugs can also weaken the intestinal barrier.

    Ability to recover after 'maximum effort' is crucial to make football's top flight | real questions and Pass4sure dumps

    Footballers' ability to recover after high-intensity effort may not depend on their age, but on their division level, a new study has suggested.

    A multinational team of scientists led by the Complutense University of Madrid (UCM) carried out maximum-effort tests with Spanish division one and division two soccer players.

    They then measured the players' oxygen consumption, heart rate and ventilation during recovery.

    Professor Francisco Javier Calderón Montero, from UCM, is the study's lead author. He said: "Regardless of a player's technical ability, the ability to repeat sprints is essential in soccer. Players may need to sprint every 90 seconds during a game, meaning the available recovery time will be short."

    "We wanted to discover if the difference in the recovery time before the next sprint were linked to the level at which a soccer player competes."

    The researchers' findings, published today in Physiological Measurement, show that compared to first division players, second division players took longer to recover from maximum effort exertion.

    Professor Montero explained: "Our results showed second division players had higher oxygen consumption and heart rate than first division players after 90 seconds of recovery time. These differences were still clear after 180 seconds of recovery time."

    "The second division players, therefore, took much longer to recover to the point where they were able to repeat the effort. They are therefore unlikely to be able to repeat sprints as often and as intensely as first division players."

    A huge sample of one-hundred-and-ninety-four male soccer players, from seven clubs in the Spanish Professional Football League, took part in the study. There were 114 first division and 80 second division players comprising: 12 goalkeepers, 57 defenders, 86 midfield players, and 39 strikers.

    All underwent the same maximum effort test. They first warmed up by running on a treadmill for two minutes at 4 km/h, before increasing their speed until they reached a heart rate of 120-130 bpm. They maintained this for three minutes. After this warm-up period, they could rest to stabilize the respiratory quotient (RQ) at <1). Researchers recorded the players' carbon dioxide production and RQ every 10 seconds.

    The maximum effort test began at a speed of 6 km/h, and a one per cent slope. The players' running speed increased by 2 km/h every two minutes until they reached maximum effort. The players then underwent a three-minute period of active recovery.

    Although the team found a difference in recovery time between players from divisions one and two, the position in which they played had no bearing on the results.

    Corresponding author Dr. Luca Paolo Ardigò, from the University of Verona, said: "A possible explanation may be that the second division players always played in lesser category clubs with lower training demands. However, the players in their study showed no differences in self-declared duration of training or weekly recovery."

    "It is possible that the intensity of training differed, and further study is needed to uncover whether this is a factor."

    More information: 'Cardio-respiratory values during recovery from exercise in soccer Spanish leagues' 2018 Physiol. Meas. 39 105003, DOI: 10.1088/1361-6579/aae0e8

    Citation: Ability to recover after 'maximum effort' is crucial to make football's top flight (2018, October 11) retrieved 17 April 2019 from

    This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

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