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000-153 System x Sales Specialist V6

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000-153 exam Dumps Source : System x Sales Specialist V6

Test Code : 000-153
Test Name : System x Sales Specialist V6
Vendor Name : IBM
: 120 Real Questions

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IBM IBM System x Sales

IBM (IBM) Outpaces stock Market positive factors: What you should comprehend | killexams.com Real Questions and Pass4sure dumps

IBM (IBM) closed essentially the most recent buying and selling day at $116.sixty seven, moving +0.49% from the outdated buying and selling session. This circulation outpaced the S&P 500's each day gain of 0.01%. in the meantime, the Dow gained 0.35%, and the Nasdaq, a tech-heavy index, delivered 0.forty five%.

Heading into these days, shares of the know-how and consulting company had lost three.5% over the last month, outpacing the desktop and know-how sector's loss of 5.fifty one% and the S&P 500's lack of 7.29% in that point.

Wall road could be hunting for positivity from IBM because it processes its subsequent income file date. this is anticipated to be January 17, 2019. On that day, IBM is projected to document revenue of $4.85 per share, which would symbolize a yr-over-year decline of 6.37%. meanwhile, the Zacks Consensus Estimate for salary is projecting web income of $21.77 billion, down 3.forty five% from the year-ago length.

searching at the full yr, their Zacks Consensus Estimates imply analysts predict salary of $13.eighty one per share and profits of $79.fifty six billion. These totals would mark adjustments of +0.07% and +0.fifty three%, respectively, from remaining yr.

it's additionally critical to be aware the recent alterations to analyst estimates for IBM. These revisions customarily replicate the latest brief-time period company tendencies, that could change often. subsequently, they are able to interpret high quality estimate revisions as a very good signal for the enterprise's company outlook.

research suggests that these estimate revisions are without delay correlated with near-term share price momentum. traders can capitalize on this by using the Zacks Rank. This mannequin considers these estimate alterations and provides a simple, actionable ranking gadget.

starting from #1 (amazing buy) to #5 (robust sell), the Zacks Rank equipment has a proven, backyard-audited tune record of outperformance, with #1 stocks returning an average of +25% yearly considering 1988. over the last month, the Zacks Consensus EPS estimate remained stagnant. IBM at present has a Zacks Rank of #2 (purchase).

its valuation, IBM is preserving a ahead P/E ratio of eight.four. For assessment, its industry has a regular forward P/E of eight.67, which capability IBM is buying and selling at a reduction to the group.

buyers should also notice that IBM has a PEG ratio of 1.69 right now. This accepted metric is similar to the widely-well-known P/E ratio, with the change being that the PEG ratio additionally takes into consideration the enterprise's anticipated profits growth fee. IBM's business had a typical PEG ratio of 1.69 as of the day past's close.

The computer - built-in systems industry is a component of the computer and technology sector. This business presently has a Zacks industry Rank of 102, which places it in the right 40% of all 250+ industries.

The Zacks trade Rank gauges the energy of their business companies with the aid of measuring the general Zacks Rank of the individual shares in the corporations. Their analysis shows that the appropriate 50% rated industries outperform the bottom half through a factor of two to 1.

be certain to utilize Zacks. Com to observe all of these inventory-moving metrics, and greater, in the coming trading classes.

desire the newest concepts from Zacks investment analysis? these days, that you can download 7 gold standard stocks for the next 30 Days. click to get this free report international company Machines agency (IBM) : Free stock evaluation report To examine this text on Zacks.com click on right here.


IBM's $34 billion purple Hat acquisition came after deal talks with Microsoft, Google, and Amazon, sources say | killexams.com Real Questions and Pass4sure dumps

When IBM introduced its $34 billion acquisition of red Hat on October 28, the tech observe was struck through the massive rate tag, as well as its expertise to revive IBM's struggling cloud company. however because it seems, issues might have long past a whole lot in another way.

Microsoft, Google, and Amazon all engaged in deal discussions with purple Hat and regarded intently into an acquisition within the months and weeks earlier than purple Hat struck a deal with IBM, according to sources common with the deal.

As an open-supply utility enterprise, purple Hat is strategic on account of its recognition with developers. or not it's also is the greatest industrial maker of the Linux working equipment. IBM wanted the know-how to boost its hybrid-cloud task and to provide its portfolio an facet.

red Hat indicated in a public filing on November 30 that three unnamed companies regarded making bids apart from IBM. CNBC pronounced in October that Google had looked into purchasing purple Hat. however Microsoft and Amazon's deal talks with purple Hat haven't been in the past said.

purple Hat's shareholders will vote on no matter if or now not to approve IBM's offer on January sixteen, 2019. The deal stands out as the greatest acquisition in IBM's 100-year-plus background and would instantly catapult IBM into the accurate ranks of cloud providers, a quick-starting to be trade that is lengthy been the domain of Amazon and Microsoft.

pink Hat rejected IBM's first offer

the primary spark of an IBM-crimson Hat merger began at an April lunch between IBM CEO Ginni Rometty and pink Hat CEO Jim Whitehurst, in keeping with remarks Rometty made on the time of the deal.

notwithstanding IBM in the end made a winning offer of $190 a share, it took some negotiation from crimson Hat. IBM at first offered $185 a share on September 27, but pink Hat's board of directors determined it turned into "insufficient," in accordance with the proxy.

purple Hat's board additionally asked its advisers to make an inventory of different capabilities acquirers, who purple Hat courted until relocating forward on the IBM deal on October 21. On October 28, the deal was introduced.

examine more: They spoke with 7 insiders about IBM's $34 billion crimson Hat takeover — right here's the way it came together

each person else declined to bid

Microsoft, which, in accordance with one source, is referenced during the proxy remark as "celebration A," first expressed pastime in red Hat returned in March. however Microsoft dropped out of the working on October 10, in keeping with the proxy, "citing issues about securing regulatory approvals of a strategic transaction within the US and Europe."

Microsoft declined to remark.

Google, which one supply referred to became "birthday party B," met with red Hat within the spring of 2018 to focus on partnerships. As a take care of IBM acquired nearer, Google continued to move forward with the sale procedure, however stopped short of creating a proposal.

Google Cloud CEO Diane Greene, who's stepping down from the position in January 2019, spent months pink Hat. Google

although Google's former Cloud CEO Diane Greene spent loads of time with red Hat ahead of its sale, she struggled to get guide from the enterprise on her colossal mergers-and-acquisitions aspirations, based on one source.

So on October 20, Google officially declined to submit a proposal and as a substitute requested if red Hat would explore a industrial partnership and a minority fairness funding from Google.

Google did not instantly return a request for comment.

Amazon, which one source talked about was "birthday party C," got worried around October 12, when crimson Hat's executives reached out to the enterprise to see if they have been attracted to a deal, in response to the proxy. however on October 20, Amazon instructed red Hat that it wasn't ready to make an offer.

despite its participation within the method, one source referred to it become possible Amazon turned into purchasing time. The enterprise wasn't attracted to purple Hat, the source pointed out, so a whole lot as it turned into in staying on exact of what its cloud competitors at Microsoft and Google have been up to.

Amazon didn't instantly return a request for comment.


IBM, Nvidia associate On New Converged Infrastructure Optimized For AI | killexams.com Real Questions and Pass4sure dumps

IBM Tuesday accelerated its reach into the burgeoning synthetic intelligence market with the introduction of a new converged infrastructure appliance marrying its all-flash storage expertise with excessive-efficiency GPU-primarily based servers from Nvidia.

large Blue's IBM SpectrumAI is a brand new reference architecture optimized for AI workloads, said Eric Herzog, chief advertising and marketing officer and vp of worldwide storage channels for IBM's storage division.

The IBM SpectrumAI is targeted at new markets just starting to open up for channel partners, Herzog advised CRN.  

[Related: IBM Doubles Down On Flash, NVMe As It Commits To Taking Storwize 100 Percent Through Channel]

These encompass self sustaining using, location-based promoting, manufacturing high-quality and assurance analysis, scientific drug trials, genomics, drilling exploration sensor evaluation, purchaser sentiment analysis and greater, he pointed out.

the new converged infrastructure for synthetic intelligence workloads brings channel partners a comprehensive strategy to the AI records pipeline, Herzog referred to.

"it's extensible and composable, and can span the records pipeline from ingest to archive," he observed.  

better of all, Herzog talked about, the IBM SpectrumAI will go to market one hundred percent via indirect sales channels.

The IBM SpectrumAI isn’t IBM's first foray into providing a converged infrastructure platform on which to run AI workloads.

IBM in June introduced its first AI-based reference structure, but it surely combined IBM's FlashSystem all-flash storage with the enterprise's power-based servers, making it an all-IBM offering, Herzog observed.

the primary storage seller to associate with Nvidia became Mountain View, Calif.-based mostly Pure Storage, which in April delivered AI-capable Infrastructure, or AIRI, which combines its all-flash FlashBlade storage with Nvidia's DGX-1 GPU-based mostly platform and Arista networking. The enterprise in may additionally followed up with AIRI Mini, a lower-charge edition featuring a lower-cost entry configuration and the alternative of Cisco Nexus 9000-based networking.

NetApp in August added its rival, the NetApp Ontap AI, which mixes NetApp's AFF A800 all-flash storage array with end-to-conclusion NVMe efficiency, Nvidia's DGX GPU nodes, and 100-Gbit Ethernet switches from Cisco into a converged platform for AI workloads.  

Herzog stated that IBM has differentiated its AI-concentrated converged infrastructure offerings in a number of methods, including having the most potent offering out there thanks to its vigor server line, in addition to multiple rate features for its Nvidia-based mostly edition.

IBM is additionally entertaining in its application stack for its IBM SpectrumAI, Herzog pointed out.  

The IBM SpectrumAI comes with Spectrum Scale, the business's scale-out file system designed for large information analytics, he stated.

options include the addition of OBM Cloud Object Storage for top-performance facts archiving; IBM Spectrum find, which uses metadata to manipulate data; and IBM Spectrum Archive for archiving facts to tape, he stated.

The IBM SpectrumAI is based on IBM's FlashSystem all-flash storage array with all-NVMe efficiency, giving it a throughput of 120 GBps in a rack and over 30 GBps sustained random examine in a 2U footprint.

shoppers can scale the offering to up to nine Nvidia DGX-1 servers with up to two GPUs in a rack while scaling storage from a single 300-TB node to up to eight Exabytes of information, Herzog spoke of.

purchasers will embody the IBM Spectrum AI, and many will say that it's about time that IBM provided such an answer, talked about Kevin Carrington, vice chairman of sales at Lighthouse desktop functions, a Lincoln, R.I.-based solution issuer and longtime IBM and Nvidia channel partner.

"clients see the marriage of Nvidia GPU-based mostly server technology with flash storage as fueling a mess of enterprise alternatives," Carrington advised CRN.  

Lighthouse desktop functions is already working with the IBM vigour-based mostly artificial intelligence platform in the health-care market, Carrington observed. "This has truly put a spring lower back into the step of power," he spoke of. "It made energy sexy once more."

no matter if vigor-primarily based or Nvidia-primarily based, IBM's synthetic intelligence platforms tackle true-world consumer requirements, Carrington talked about.  

"AI is far and wide," he mentioned. "or not it's how they are ingesting IT, and how the marketplace sees us as patrons. it's throughout us, and it be occurring these days."


000-153 System x Sales Specialist V6

Study Guide Prepared by Killexams.com IBM Dumps Experts


Killexams.com 000-153 Dumps and Real Questions

100% Real Questions - Exam Pass Guarantee with High Marks - Just Memorize the Answers



000-153 exam Dumps Source : System x Sales Specialist V6

Test Code : 000-153
Test Name : System x Sales Specialist V6
Vendor Name : IBM
: 120 Real Questions

Worried for 000-153 exam? Get this 000-153 question bank.
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The killexams.com is the great web page where my desires come true. by way of the usage of the material for the practise genuinely brought the actual spark to the studies and seriously ended up through acquiring the high-quality rating in the 000-153 exam. its miles pretty clean to stand any examination with the help of your observe fabric. thanks a lot for all. preserve up the super paintings men.


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System x Sales Specialist V6

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These 2019 new car models are hitting dealerships now (or arriving soon) | killexams.com real questions and Pass4sure dumps

If you follow the automotive industry — or if you’re thinking about buying a new vehicle anytime soon — this is one of the best times of year to follow the latest releases and developments as automakers turn their attention to 2019 and 2020.

To keep tabs on them all, we’ve compiled a list of the new 2019 model year vehicles … so far. Keep checking in, as we’ll add new cars as they debut.

Coming Soon 2019 Audi A7

The Audi A7 was one of the early arrivals to the “four-door coupe” segment back in 2012. In its first major redesign, the 2019 A7 pulls styling cues from the A8 flagship sedan, including the front fascia design and interior layout. The cabin swaps out the MMI dial of previous models for a dial-screen layout, including a 10.1-inch upper screen and an 8.6-inch lower screen.

The A7 now comes as a mild hybrid, working with the 3.0-liter V6 to produce 340 horsepower and 368 pound-feet of torque.

The A7 will start at $68,000, which is actually $1,700 less than the outgoing model. Availability has not been announced.

Boston.com Dealer Specials: 2019 Audi E-Tron

Audi is making a smallish SUV as its first mass-produced electric vehicle. It features two electric motors, one at the front wheels and one at the rear. They make 168 horsepower (182 pound-feet of torque) and 188 horsepower (232 pound-feet), respectively. Sport mode instantly increases output by 13 horsepower (46 pound-feet) and 33 horsepower (30 pound-feet). Power is stored in a 95 kWh battery pack and will have an estimated range of around 210 miles.

The E-Tron starts at $74,800 for the Premium Plus trim and $81,800 for the Prestige trim, placing it near Tesla Model S and Model X entry-level range.

2019 BMW 3 Series

The 3 Series is the cornerstone of the BMW lineup; over 15 million have been sold since 1975. This popular luxury sedan has been redesigned for 2019 with many innovations including Reversing Assistant, which records the last 50 meters of forward motion and reverses the vehicle along the same path. The 3 Series also features Intelligent Personal Assistant, which is like Siri for a car.

The 3 Series will be initially offered as the 330i, equipped with a 2.0-liter, turbocharged four-cylinder making 255 horsepower and 295 pound-feet of torque. It will be joined by the M340i in 2019 and 330e plug-in hybrid in 2020.

Base MSRP for the 2019 BMW 330i is $41,195, while the all-wheel drive 330i xDrive costs $43,245. The new 3 Series is expected to hit dealers in March 2019.

2019 BMW 8 Series

The BMW M850i features a long hood, and underneath is a twin-turbocharged V8 making 523 horsepower and 553 pound-feet of torque. It sends power to standard xDrive all-wheel drive. The convertible variant’s roof opens or closes in 15 seconds at speeds up to 30 miles per hour.

Inside, the 8 Series features a 12.3-inch touchscreen. It runs the latest version of BMW’s iDrive, and it integrates Microsoft Office 365 and Skype for Business. Other features include a digital display key fob, Bowers & Wilkins stereo, and an available M Sport Package.

Base MSRP for the Coupe is $111,895, while the convertible will cost $9,500 more, coming in at $121,395. The BMW 8 Series is expected to go on sale in fall 2019.

2019 BMW X7

You’ll instantly recognize the BMW X7 not only for its size, but the size of its grille. Inside, you’ll find three rows and seating for up to seven, or six if you opt for second-row captain’s chairs. Engine choices include a 335-horsepower twin-turbo inline-six (xDrive40i), or a twin-turbo V8 (xDrive50i) making 456 horsepower and 479 pound-feet of torque.

As the names suggest, power is routed to xDrive all-wheel drive, and the whole thing rides on an air suspension that can lower for easier access. Other neat tricks include rear-wheel steering and an adaptive suspension system with a camera scanning the road conditions ahead.

Base MSRP for the xDrive40i is $73,900, while the V8-powered xDrive50i starts at $92,600. BMW is taking orders now.

The 2019 Silverado will weigh 450 pounds less than the outgoing model, thanks to the use of aluminum for the doors, hood, and tailgate. The bed and other major components will still be high-strength steel. A power tailgate will be available, too. The new Silverado will also be available with a turbocharged four-cylinder engine and 3.0-liter Duramax diesel engine in addition to the 5.3-liter and 6.2-liter V8 gas engines. Power is routed through a new 10-speed automatic transmission. The Silverado will also offer dynamic fuel management to shut down individual cylinders and save fuel.

Base MSRP for the 2019 Chevrolet Silverado is $28,300. Some vehicles are trickling into dealerships, so you might be able to find one now. For everyone else, it’s still coming soon.

The Ford Ranger has been absent from the American truck market since 2011. The Ranger is based on Ford’s T6 global pickup, but when it arrives in the U.S. early next year, it will come with features like SYNC 3 infotainment and Wi-Fi that can connect up to 10 devices up to 50 feet from the vehicle. The standard engine is a turbocharged 2.3-liter four-cylinder making 310 horsepower and 350 pound-feet of torque.

Ford is already taking orders for the 2019 Ranger, which has a starting price of $24,000 and is expected to hit dealerships in early 2019.

2019 Mazda 3

The Mazda3 is the automaker’s global sales leader, so a redesign gets practically as much fanfare as a sports car. The new 2019 Mazda3 takes a more upscale approach. It’s 3.2 inches longer and less than an inch lower, giving it a more dramatic stance.

Inside, the vehicle features a clean, luxury-like aesthetic. The touchscreen atop the dash is now a large 8.8-inch unit that can be controlled via a joystick dial in the center console. It will be available with gas and diesel engine options, as well as Mazda’s new compression-ignition engine, combing the best attributes of both gas and diesel engines.

Pricing and availability have not been announced.

2019 Toyota Prius AWD-e

This all-wheel drive Prius retains the original drivetrain up front, but it adds an independent electric motor to the rear wheels. At speeds up to 6 miles per hour, the rear motor automatically engages — and will engage as needed — up to 43 miles per hour. Above that, it remains disengaged to conserve energy.

EPA estimates for the all-wheel drive Prius are 52/48/50 miles per gallon (city/highway/combined). Compare that with the FWD Prius, which is expected to return 58/53/56 for the LE Eco trim, and 54/50/52 for the rest of the trim lineup.

The Prius AWD-e will start at $27,300 for the LE Eco trim and $39,740 for the XLE. Availability has not been announced.

At Dealerships Now 2019 Acura RDX

Behind the massive new grille of the 2019 RDX is a new direct-injected 2.0-liter turbocharged four-cylinder engine. It’s mated to a new 10-speed automatic transmission. Inside, the RDX gets a new 10.2-inch display that’s operated via touchpad.

Pricing ranges from $37,300, up to $45,400 for an Advance Package model.

2019 Ford Edge

The Ford Edge has been redesigned for 2019, and this spacious two-row crossover is loaded with refinements and features. The all-new Edge ST effectively replaces the Edge Sport, and it features performance-inspired styling backed by a 2.7-liter EcoBoost twin-turbo V6 making 335 horsepower and 380 pound-feet of torque. Ford will also offer Titanium as a luxury-minded trim.

The Edge starts at $29,995, while the ST starts at $42,355.

2019 Honda Insight

The 2019 Insight is the third Honda vehicle to wear the “Insight” name, and this time around, it’s positioned as a replacement for the Honda Civic Hybrid. It employs a two-motor full-hybrid system that’s capable of an impressive 55 miles per gallon in the city, 49 on the highway, and 52 combined. It also has Honda’s updated (and finally easy-to-use) infotainment system, as well as Honda Lane Watch and Honda Sensing safety technologies.

The 2019 Honda Insight starts at $22,830.

2019 Hyundai Veloster

Hyundai’s quirky Veloster hatchback continues to offer its strange 1+2 door layout, which features one large door on the driver’s side and smaller front/rear doors on the passenger side. It’s all-new inside and out, and it continues to offer a very unique appearance. Inside, the Veloster gets a sharp interior with a large, floating touchscreen. Hyundai’s new N performance line now extends to the Veloster and boasts a turbocharged inline-four making 275 horsepower.

The 2019 Veloster starts at $18,500.

The Jeep Cherokee is one of the most capable small SUVs on the market. The one polarizing element to this SUV has been its futuristic-looking front end. Jeep heard the criticism, and so it debuted a more conventional front fascia with the 2019 edition. A new 2.0-liter turbocharged inline-four joins the lineup, putting out 270 horsepower and 295 pound-feet of torque.

The base Latitude comes in $300 less than the outgoing model, now priced at $25,190.

2019 Kia Forte

The redesigned Kia Forte takes styling inspiration from the new Stinger GT performance sedan. It is now 3.2 inches longer, allowing for a more spacious interior. The interior is also more upscale and features a floating infotainment screen similar to its corporate cousin: the Hyundai Elantra GT.

Its 2.0-liter inline-four makes 147 horsepower and 132 pound-feet of torque. This engine returns as much as 35 miles per gallon combined.

The 2019 Kia Forte has a base MSRP of $17,690.

2019 Mini Cooper

Like the Jeep Wrangler or Porsche 911, the Mini Cooper thrives on the continual evolution of its iconic heritage design. Subtle updates to the two-door, five-door, and convertible variants include new headlight clusters, along with tail lights with the Union Jack integrated into their design. A 6.5-inch touchscreen is standard but can be updated to an 8.8-inch navigation system.

The 2019 Mini Cooper starts at $21,900.

For 2019, the Ram loses its iconic “crosshair” grille, emphasizing variation in styling among its wide range of trims. Under the hood, the V6 and V8 gas engines now feature eTorque mild-hybrid integration for improved fuel efficiency. It adds up to 90 pound-feet of torque to the V6 and 130 pound-feet to the V8 engine. A 3.0-liter diesel V6 is also available.

The Ram 1500 is now available with a massive 12-inch touchscreen. This reconfigurable screen is arranged in portrait layout, much like the Tesla Model S. Out back, an available hydraulic tailgate lets you open and close it remotely.

The 2019 Ram 1500 starts at $31,795.

2019 Toyota Avalon

Toyota is taking the generally staid Avalon in a more aggressive direction with its 2019 model. The sporty styling is backed by a 3.5-liter V6 making 301 horsepower and 267 pound-feet of torque. A hybrid variant will also be available, and it should improve on the 2018 model’s fuel economy of 40 miles per gallon in the city and 39 on the highway.

The Avalon gets a spacious, well-equipped cabin, and it’s one of the first Toyota vehicles to offer Apple CarPlay and Android Auto. It’s also available with a 1,200-watt JBL sound system and a color heads-up display.

Base MSRP for the 2019 Toyota Avalon is $35,500.

The completely redesigned 2019 Volkswagen Jetta is larger and more substantial than its predecessor. Its 1.4-liter turbocharged base engine makes just 147 horsepower, but with its new eight-speed automatic transmission, the vehicle returns fuel economy of 30 miles per gallon in the city and 40 on the highway. The new-look Jetta gets a far more engaging interior, complete with a large touchscreen, ambient lighting, and the “Volkswagen Digital Cockpit.” This 10-inch digital display replaces the conventional instrument panel and has six information modes.

The 2019 Jetta starts at $18,545.


Getting the Most Out of the CLARITY Technique | killexams.com real questions and Pass4sure dumps

An interview with Dr. Tim Steppe (Ph.D.) from Logos Biosystems at SfN 2018, discussing the latest advances in the CLARITY technique and his top tips for scientists using this method in their research.

What makes CLARITY such a useful research technique for neuroscientists?

CLARITY allows researchers to map projections in neurons by carrying out in-depth 3D imaging on organs and tissues. The brain is one of the best tissues that you can image using this method as it has such a high lipid content. CLARITY allows researchers to trace pathways of neurons, look at connections, and potentially look at discontinuities between healthy and altered states.

Pink illustration of the human brain - used to study neurological diseases with the CLARITY technique - by 80's Child80's Child | Shutterstock

Some of the early examples of using CLARITY were researching drug addiction in mice within the lab and the modeling of disease. CLARITY provides researchers with the ability to see the brain in more detail and to develop an understanding of how it's organized at the cellular level.

What kinds of neurological diseases can CLARITY be used to study?

All sorts of diseases! It can also be used to study neuronal development and how structures grow and project. The major application of CLARITY is the study of disease states, such as Alzheimer’s disease, to be compared to normal states. It has also been used to look at glioblastoma, Parkinson's disease, and other neurological lesions.

What challenges have researchers faced in the past when performing CLARITY?

After Karl Deisseroth’s lab at Stanford University released the method in 2013, researchers began trying to build their own homegrown electrophoretic systems. Biologists are not usually engineers, so many ran into all sorts of problems that led to poorly cleared or ruined samples.

At Logos Biosystems, they have engineered the X-CLARITY systems and reagents for tissue clearing that allows researchers to reliably and consistently clear tissues. This prevents researchers from ruining their sample and provides reproducible clearing from sample to sample.

What is the X-CLARITY and what benefits does it offer over manually carrying out the technique?

The most important thing for everyone: time.  After researchers began exploring CLARITY, they realized that it was also a really great technique for clearing tissues from the brain tissue, but also for clearing lipids from other tissues and organs. However, the lack of success with many homemade systems drove many researchers back to a passively clearing their samples, where no current is applied help remove lipids. The issue with this is that you're running into weeks and weeks of clearing time.

With the X-CLARITY, researchers can clear up to six whole brains in as little as 7 to 12 hours. Rather than weeks to months for passive clearing, With the X-CLARITY, it now only takes hours.

Previously, when people wanted to build a 3D image or model of their system, they had to painstakingly slice samples down to 20 to 30 microns, prep those samples, image each separately, and then stitch them together.

CLARITY allows people to better leverage optical sectioning technology, which is just a fancy way to describe either a confocal microscope, a light sheet microscope, or a multiphoton microscope. Once the lipids have been removed, these systems are able to delve deep into the sample, generating better images in a far faster manner.

Another aspect is flexibility. The X-CLARITY allows the current, voltage, and temperature to be modulated, depending on the sample type. This allows researchers to optimize the conditions for their own particular sample and model system.

We have a general set of guidelines that they provide to help researchers, but every sample or every model system is going to be slightly different. They have developed protocols and parameters that will work fairly well for everything, with the ultimate tweaking and optimization coming from the researchers themselves.

Why did you feel it was important to develop a CLARITY solution for antibody labeling?

With the multi-sample holders that we've developed and speed of the X-CLARITY system, the bottleneck in time now falls to antibody labeling. With their new labeling kit, we've halved the amount of time it takes to stain the sample.

Conventional antibody labeling with a cleared whole mouse brain sample can require a 7 to 14 day incubation period with each antibody – primary and secondary – meaning it can take anywhere between two to four weeks to do the labeling. With the DeepLabel Antibody Staining Kit, however, it only requires a total of 7 days for a whole mouse brain.

The other benefit of their labeling kit is that it increases the binding of the antibodies to the targets. This applies not only to clear, thick tissue samples, but also thin sections.  So, for example, it can help increase the binding of antibodies to recalcitrant targets such as neurotransmitters.

Synapse showing neurotransmitters -illustration by nobeastsofiercenobeastsofierce | Shutterstock

What are the next steps for your company, and the technologies you produce?

Over the next few years, they would like to be able to provide a complete solution to the entire tissue clearing workflow. Their overall goal is to provide researchers with an entire system which delivers clear tissues, images, and analysis.

Our immediate next steps will include improving the clearing method and the antibody labeling kit that they have developed, and then developing a light sheet microscope that is optimized for use with CLARITY.

Our core mission is to develop innovative cellular imaging and analysis tools.  Currently, their main product line is automated cell counters along with automated microscopes for screening and other high-throughput studies.

Where can readers find more information?

A step-by-step guide to CLARITY by Logos Biosystems.

About Dr. Tim Steppe

Portrait image of Tim Steppe, the intervieweeTim Steppe has Ph.D. in Marine Sciences from UNC-Chapel Hill and has 15 years of industry experience mostly spent with start-ups and smaller companies in various roles including tech support, sales, and marketing.

In his current role as an Application Specialist at Logos Biosystems, Tim is responsible for customer and sales force education and market development for new Logos products.

About Logos Biosystems

Logos Biosystems specializes in developing life science tools and technologies for a wide spectrum of applications including basic research, quality control, and drug discovery. Since its founding in 2008, Logos Biosystems has been developing a series of automated systems and imaging instruments for laboratories engaging in research with a cellular and molecular emphasis.


Trump Officials Say Drug Prices Are Inflated. So Are Some of Their Claims on a Solution. | killexams.com real questions and Pass4sure dumps

“For at least 30 percent of Part B spending, Medicare prices are at least half of the market, meaning there is effectively no competition within that substantial federal spending among competing products,” said John O’Brien, the senior adviser on drug pricing at the Department of Health and Human Services.

What was said

“This model will expand patient access, through lower prices. This is a pro-patient-access model. They are going to lower drug prices substantially, for their most costly drugs, without restrictions on patient access.”

— Mr. Azar in October

This lacks evidence.

Under Mr. Trump’s proposal, Medicare payment for physician-administered drugs would be based, in part, on prices in other countries, including some that restrict access to drugs by limiting coverage.

The administration assumes that Medicare can pay lower prices without limiting access. This assumption is based on a belief that drug manufacturers could not walk away from the Medicare market because it is so large, with 55 million people in Part B.

Moreover, Medicare officials say they would monitor the use of prescription drugs to ensure that beneficiaries’ access to medicines is not compromised. Even with the pricing index, they say, Medicare would still be paying more than the average of other countries.

But some advocates for patients are apprehensive.

“We share the administration’s goal of reducing prescription drug costs,” said Christopher W. Hansen, the president of the advocacy arm of the American Cancer Society, but the proposal “raises numerous questions about beneficiary access.”

“For instance,” Mr. Hansen said, “how would patients access necessary care if there are no vendors willing to bring drugs to physicians in their area? What if the drug maker decides not to sell a particular drug at the price required under the proposal, and patients are unable to get the Medicare-covered drugs they need to treat their disease?”

Dr. Debra Patt, a breast cancer specialist at Texas Oncology, a group of more than 400 doctors, asked: “What leverage would a vendor have to bring manufacturers to the table? Suppose a manufacturer is selling drug X for $1,000, and the vendor wants to pay only $750. What if the manufacturer says no? What then happens to Medicare beneficiaries?”



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